Recombinant Human BEND6 Protein

Beta LifeScience SKU/CAT #: BL-3666PS
Recombinant Human BEND6 Protein

Recombinant Human BEND6 Protein

Beta LifeScience SKU/CAT #: BL-3666PS
Catalog No.: BL-3666PS

Product Overview

Tag N/A
Host Species Human
Synonym BEN Domain Containing 6, C6orf65, Chromosome 6 Open Reading Frame 65, bA203B9.1, BEN Domain-Containing Protein 6, BEND6.
Background BEN domain-containing protein 6 (BEND6) is a neural BEN-solo factor which shares many functional attributes with Drosophila Insensitive, a co-repressor for the Drosophila CSL factor. The BEND6 protein binds the mammalian CSL protein CBF1 and antagonizes Notch-dependent target activation. Furthermore, its association with Notch- and CBF1-regulated enhancers is stimulated by CBF1 and antagonized by activated Notch. In utero electroporation experiments demonstrated that ectopic BEND6 impeded Notch-mediated self-renewal of neocortical neural stem cells and promoted neurogenesis.
Description BEND6 Human Recombinant expressed in E.Coli is a single, non-glycosylated polypeptide chain containing 302a.a. (1-279 a.a) and having a molecular weight of 33.6kDa.BEND6 is fused to a 23a.a. His-tag at N-terminus and purified by unique purification methods.
Source E.coli
AA Sequence MGSSHHHHHH SSGLVPRGSH MGSMQKIVQT DEITNTQAFR KGKRKRTETM DSENANSDMD KGQRDPYSGN AFLPGESSSE DEEPLAELSK EELCAKIKSL KEKLTNTRKE NSRLRQSLVM LQVLPQAVTQ FEELVGMAEA LLKGGGTMST SASTLWRATN NSSPDSFAST CSNSNSNSSS PVSLKPEEEH QTDEKQFQIE KWQIARCNKS KPQKFINDLM QVLYTNEYMA THSLTGAKSS TSRDKAVKPA MNQNEVQEII GVTKQLFPNT DDVSIRRMIG QKLNNCTKKP NLSKNLNSQD IK.
Purity >90.0% as determined by SDS-PAGE.
Endotoxin <1.0 EU per μg by the LAL method.
Formulation BEND6 protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.1M NaCl.
Stability Recombinant protein is stable for 12 months at -70°C
Usage For Research Use Only
Storage Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Recently viewed