Recombinant Human BD3 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0389
Recombinant Human BD3 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0389
Catalog No.: BLPSN-0389
Product Overview
| Tag | His |
| Host Species | Human |
| Accession | P81534 |
| Synonym | BD-3, DEFB-3, DEFB103, DEFB3, hBD-3, HBD3, HBP-3, HBP3 |
| Background | Beta-defensin 3 is a member of the defensin family. Defensin family is comprised by microbicidal and cytotoxic peptides made by neutrophils. Members of the beta-defensin 3 family are highly similar in protein sequence. Beta-defensin 3 shows antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Beta-defensin 3 is abundantly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. It is also expressed in salivary gland, bone marrow, colon, stomach, polyp and larynx. However, in small intestine, it cannot be detected. Defensin has broad spectrum antimicrobial activity and may play an important role in innate epithelial defense. Beta-defensin 3 kills multiresistant S.aureus and vancomycin-resistent E.faecium. It has no significant hemolytic activity. |
| Description | A DNA sequence encoding the mature form of human DEFB103A (P81534) (Gly 23-Lys 67) was expressed, with a His tag at the N-terminus. |
| Source | E.coli |
| Predicted N Terminal | Met |
| AA Sequence | Gly 23-Lys 67 |
| Molecular Weight | The recombinant human DEFB103A consists of 61 a.a. and predicts a molecular mass of 7.3 KDa. It migrates as an approximately 12 KDa band in SDS-PAGE under reducing conditions. |
| Purity | >99% as determined by SDS-PAGE |
| Endotoxin | Please contact us for more information. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile 50mM Tris, 0.3% Ttiton X-100, 0.3% SKL, pH 8.5. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
