Recombinant Human BAFFR Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0348
Recombinant Human BAFFR Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0348
Catalog No.: BLPSN-0348
Product Overview
| Tag | Fc |
| Host Species | Human |
| Accession | NP_443177.1 |
| Synonym | BAFF-R, BAFFR, BROMIX, CD268, CVID4, prolixin |
| Background | Tumor necrosis factor receptor superfamily, member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen, is a member of the tumor necrosis factor receptor superfamily. A tumor necrosis factor receptor (TNFR), or death receptor, is a trimeric cytokine receptor that binds tumor necrosis factors (TNF). The receptor cooperates with an adaptor protein which is important in determining the outcome of the response. Members of the TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity and in cellular apoptosis process. Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors or tumour necrosis factor (TNFR), on their surface. Tumour necrosis factors (TNFR) detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery. It has been proposed that abnormally high levels of BAFFR/TNFRSF13C (CD268) may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. |
| Description | A DNA sequence encoding the human TNFRSF13C (NP_443177.1) (Arg2-Ala71) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Arg 2 |
| AA Sequence | Arg2-Ala71 |
| Molecular Weight | The recombinant human TNFRSF13C consists of 308 a.a. and predicts a molecular mass of 33.9 kDa. |
| Purity | >95% as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
