Recombinant Human ANTXR2 Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0225
Recombinant Human ANTXR2 Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0225
Catalog No.: BLPSN-0225
Product Overview
| Tag | Fc |
| Host Species | Human |
| Accession | NP_477520.2 |
| Synonym | CMG-2, CMG2, HFS, ISH, JHF |
| Background | Loss-of-function mutations in capillary morphogenesis gene 2 (CMG2/ANTXR2), a transmembrane surface protein, cause hyaline fibromatosis syndrome (HFS), a severe genetic disorder that is characterized by large subcutaneous nodules, gingival hypertrophy and severe painful joint contracture. Anthrax toxin causes anthrax pathogenesis and expression levels of ANTXR2 (anthrax toxin receptor 2) are strongly correlated with anthrax toxin susceptibility. A recent genome-wide association study or GWAS identified that anthrax roxin receptor 2 (ANTXR2) was one of the risk loci for ankylosing spondylitis (AS). Previous study also showed that ANTXR2 could potentially affect new bone formation. This study aimed to investigate the possible mechanisms of ANTXR2 involved in AS pathogenesis. |
| Description | A DNA sequence encoding the human ANTXR2 (NP_477520.2) (Met1-Asn317) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Gln 34 |
| AA Sequence | Met1-Asn317 |
| Molecular Weight | The recombinant human ANTXR2 consists 522 a.a. and predicts a molecular mass of 57.4 kDa. |
| Purity | >(81.1 + 8.8)% as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
