Recombinant Human ALK-1 Protein
Beta LifeScience
SKU/CAT #: BL-0305SG
Recombinant Human ALK-1 Protein
Beta LifeScience
SKU/CAT #: BL-0305SG
Catalog No.: BL-0305SG
Product Overview
| Tag | GST |
| Host Species | Human |
| Accession | NM_000020 |
| Synonym | ACVRL1, ACVRLK1, ALK1, HHT, HHT2, ORW2, SKR3, ALK1, TSR-I |
| Background | ALK1 is a serine/threonine-protein kinase receptor R3 precursor that mediates signal by TGFbeta superfamily (1). ALK1 functions as a TGFbeta type I receptor in endothelial cells and is responsible for human hereditary hemorrhagic telangiectasia (HHT) type II. Distinct Smad proteins (i.e., Smad2/Smad3 and Smad1/Smad5) show interaction with ALK1 and mediate TGFbeta signaling. Northern blot and RT-PCR analysis show that ALK1 specifically induces expression of Smad6, Smad7, Id1, Id2, endoglin, STAT1, and interleukin 1 receptor in endothelial cells. ALK1 expression in inflammatory myofibroblastic tumor of the urinary bladder have also has been reported (2). |
| Description | Recombinant human ALK1 (144-end) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods. This protein is purified with our unique purification methods. |
| Source | Sf9 insect cells |
| AA Sequence | 144a.a.-end |
| Molecular Weight | ~64 kDa |
| Purity | For specific purity information on a given lot, see related COA. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Active |
| Formulation | Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol. |
| Stability | The recombinant protein is stable for up to 12 months at -70°C |
| Usage | For Research Use Only |
| Storage | Recombinant Human ALK1 Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
