Recombinant Human ALCAM Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BL-0176NP
Recombinant Human ALCAM Protein (Fc Tag)

Recombinant Human ALCAM Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BL-0176NP
Catalog No.: BL-0176NP

Product Overview

Tag Fc
Host Species Human
Accession Q13740
Synonym ALCAM CD166 antigen; Activated leukocyte cell adhesion molecule; CD166; ALCAM; MEMD
Background Activated leukocyte cell adhesion molecule (ALCAM), also named as CD166 and MEMD, is a typeI transmembrane glycoprotein of immunoglobulin superfamily, which mediates homotypic and heterotypic interactions between cells. ALCAM is expressed on thymic epithelium, microvascular endothelium, activated lymphocytes and monocytes, and monocytederived dendritic cells. ALCAM mediates low-affinity adhesion with itself or the cysteine-rich scavenger receptor CD6 to regulate T cell development, immunological synapses(IS), and cell migration through endothelial junctions. ALCAM on thymic epithelia mediates adhesion to CD6 on CD4+CD8+ T cells. Adhesion of ALCAM expressing antigen presenting cells and CD6-expressing T cells stabilizes the early IS, while later it enhances CD3 effects on T cell proliferation, CD25 expression, and Th1 commitment. ALCAM may influence expression or adhesion of the neuronal adhesion molecule NCAML1, both in the developing retina and invasive melanoma.
Description Recombinant Human CD166 Antigen is expressed by our Mammalian expression system and the target gene encoding Trp28-Ala526 is expressed with a Fc tag at the C-terminus.
Source Human Cells
AA Sequence Trp28-Ala526
Purity >95% as determined by reducing SDS-PAGE.
Endotoxin <0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Recombinant Human ALCAM Protein was lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Dissolve the lyophilized protein in distilled water.
Usage For Research Use Only
Storage Human ALCAM protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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