Recombinant Human AKR1C4 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0119
Recombinant Human AKR1C4 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0119
Collections: Other recombinant proteins, Recombinant proteins
Product Overview
| Tag | His |
| Host Species | Human |
| Accession | AAH20744.1 |
| Synonym | 3-alpha-HSD, AKR1C4, C11, CDR, CHDR, DD-4, DD4, HAKRA |
| Background | Aldo-keto reductases comprise of AKR1C1-AKR1C4, four enzymes that catalyze NADPH dependent reductions and have been implicated in biosynthesis, intermediary metabolism, and detoxification. there is a strong correlation between the expression levels of these family members and the malignant transformation as well as the resistance to cancer therapy. Type I human hepatic 3alpha-hydroxysteroid dehydrogenase (AKR1C4) plays a significant role in bile acid biosynthesis, steroid hormone metabolism, and xenobiotic metabolism. |
| Description | A DNA sequence encoding the human AKR1C4 (AAH20744.1) (Met1-Tyr323) was expressed with a His tag at the N-terminus. |
| Source | E.coli |
| Predicted N Terminal | His |
| AA Sequence | Met1-Tyr323 |
| Molecular Weight | The recombinant human AKR1C4 consists of 341 a.a. and predicts a molecular mass of 39.4 KDa. It migrates as an approximately 35-40 KDa band in SDS-PAGE under reducing conditions. |
| Purity | >85% as determined by SDS-PAGE |
| Endotoxin | Please contact us for more information. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
