Recombinant Human Acyl-Coa-Binding Domain-Containing Protein 5 (ACBD5) Protein (His/Tag-Free)

Name: Recombinant Human Acyl-Coa-Binding Domain-Containing Protein 5 (ACBD5) Protein (His/Tag-Free)
Brand: Beta LifeScience
SKU: BLC-11295P
Availability: InStock

Collections: All products, High-quality recombinant proteins, Other recombinant proteins

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Product Overview

Description	Recombinant Human Acyl-Coa-Binding Domain-Containing Protein 5 (ACBD5) Protein (His/Tag-Free) is produced by our Yeast expression system. This is a full length protein.
Purity	Greater than 85% as determined by SDS-PAGE.
Uniprotkb	Q5T8D3
Target Symbol	ACBD5
Synonyms	Acbd5; ACBD5_HUMAN; Acyl CoA binding domain containing 5; Acyl CoA binding domain containing protein 5; Acyl Coenzyme A binding domain containing 5; Acyl-CoA-binding domain-containing protein 5; DKFZp434A2417; Endozepine related protein; KIAA1996; Membrane associated diazepam binding inhibitor; OTTHUMP00000019362; OTTHUMP00000019363; OTTHUMP00000019364; OTTHUMP00000019365; RP11-85G18.5
Species	Homo sapiens (Human)
Expression System	Yeast
Tag	N-His/Tag-Free
Protein Length	full length protein
Form	Liquid or Lyophilized powder
Buffer	Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Storage	1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target Function	Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.
Subcellular Location	Peroxisome membrane; Single-pass membrane protein.
Protein Families	ATG37 family
Database References	HGNC: 23338 OMIM: 616618 KEGG: hsa:91452 STRING: 9606.ENSP00000379568 UniGene: PMID: 27899449 ACBD5-VAPB interaction regulates peroxisome-endoplasmic reticulum associations. Loss of PO-ER association perturbs PO membrane expansion and increases PO movement. PMID: 28108524 VAP-ACBD5-mediated contact between the endoplasmic reticulum and peroxisomes mediate organelle maintenance and lipid homeostasis. PMID: 28108526 Findings suggest that the ACBD5-RET rearrangement is causatively involved in the development of papillary thyroid cancer. PMID: 25175022 Yeast Atg37, which is homologous to human ACBD5, is involved in autophagy of peroxisomes. PMID: 24905344 A mutation in the acyl-coenzyme A binding domain-containing protein 5 gene (ACBD5 ) may have a role in autosomal dominant thrombocytopenia PMID: 20626622

FAQs

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Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.

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Recombinant Human Acyl-Coa-Binding Domain-Containing Protein 5 (ACBD5) Protein (His/Tag-Free)

Recombinant Human Acyl-Coa-Binding Domain-Containing Protein 5 (ACBD5) Protein (His/Tag-Free)

Product Overview

Target Details

FAQs