Recombinant Human ABP1 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-0034
Recombinant Human ABP1 Protein (His Tag)

Recombinant Human ABP1 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-0034
Catalog No.: BLPSN-0034

Product Overview

Tag His
Host Species Human
Accession AAH14093.1
Synonym ABP, ABP1, DAO, DAO1, KAO
Background Amine oxidase copper-containing 1 (AOC1; formerly known as amiloride-binding protein 1) is a secreted glycoprotein that catalyzes the degradation of putrescine and histamine. Polyamines and their diamine precursor putrescine are ubiquitous to all organisms and fulfill pivotal functions in cell growth and proliferation. That the Wilms tumor protein, WT1, which is necessary for normal kidney development, activates transcription of the AOC1 gene. Expression of a firefly luciferase reporter under control of the proximal AOC1 promoter was significantly enhanced by co-transfection of a WT1 expression construct. Binding of WT1 protein to a cis-regulatory element in the AOC1 promoter was confirmed by electrophoretic mobility shift assay and chromatin immunoprecipitation.- WT1-dependent control of polyamine breakdown, which is mediated by changes in AOC1 expression, has a role in kidney organogenesis.
Description A DNA sequence encoding the human AOC1 (AAH14093.1) (Met1-Val751) was expressed with a His tag at the C-terminus.
Source HEK293
Predicted N Terminal Glu 20
AA Sequence Met1-Val751
Molecular Weight The recombinant human AOC1 consists 743 a.a. and predicts a molecular mass of 84.9 kDa.
Purity >90% as determined by SDS-PAGE.
Endotoxin < 1.0 EU per μg protein as determined by the LAL method.
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.4..
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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