Recombinant Cynomolgus Transferrin Receptor Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-4630
Recombinant Cynomolgus Transferrin Receptor Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-4630
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | His |
Host Species | Cynomolgus |
Accession | XP_005545315.1 |
Background | Transferrin receptor protein 1, also known as transferrin receptor, Trfr, p9, CD71 and TFRC, is a single-pass type II membrane protein which belongs to thepeptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target. |
Description | A DNA sequence encoding the cynomolgus TFRC (XP_005545315.1) (Cys89-Phe760) was expressed with a His tag at the N-terminus. Cynomolgus and Rhesus TFRC sequences are identical. |
Source | HEK293 |
Predicted N Terminal | His |
AA Sequence | Cys89-Phe760 |
Molecular Weight | The recombinant cynomolgus TFRC comprises 692 a.a. and has a calculated molecular mass of 77.6 KDa. |
Purity | >95% as determined by SDS-PAGE |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Bioactivity | Measured by its ability to neutralize transferrin-mediated effect on proliferation of MCF-7 cells.The ED50 for this effect is typically 2-10 ug/mL. |
Formulation | Lyophilized from sterile PBS, pH 7.4.. |
Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
Usage | For Research Use Only |
Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |