Recombinant Cynomolgus Transferrin Receptor Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-4630
Recombinant Cynomolgus Transferrin Receptor Protein (His Tag)

Recombinant Cynomolgus Transferrin Receptor Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-4630
Catalog No.: BLPSN-4630

Product Overview

Tag His
Host Species Cynomolgus
Accession XP_005545315.1
Background Transferrin receptor protein 1, also known as transferrin receptor, Trfr, p9, CD71 and TFRC, is a single-pass type II membrane protein which belongs to thepeptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target.
Description A DNA sequence encoding the cynomolgus TFRC (XP_005545315.1) (Cys89-Phe760) was expressed with a His tag at the N-terminus. Cynomolgus and Rhesus TFRC sequences are identical.
Source HEK293
Predicted N Terminal His
AA Sequence Cys89-Phe760
Molecular Weight The recombinant cynomolgus TFRC comprises 692 a.a. and has a calculated molecular mass of 77.6 KDa.
Purity >95% as determined by SDS-PAGE
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Measured by its ability to neutralize transferrin-mediated effect on proliferation of MCF-7 cells.The ED50 for this effect is typically 2-10 ug/mL.
Formulation Lyophilized from sterile PBS, pH 7.4..
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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