Recombinant Cynomolgus PD-1 Protein
Beta LifeScience
SKU/CAT #: BLPSN-3682
Recombinant Cynomolgus PD-1 Protein
Beta LifeScience
SKU/CAT #: BLPSN-3682
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | N/A |
Host Species | Cynomolgus |
Accession | NP_001271065.1 |
Synonym | PD-1 Programmed cell death protein 1;hPD-1;PDCD1;CD279 |
Background | Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function. |
Description | A DNA sequence encoding the cynomolgus PDCD1 (NP_001271065.1) (Met1-Gln167) was produced with a c-terminal Fc region of human IgG1 tagged AVI tag at the C-terminus. The produced protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-produced. |
Source | HEK293 |
Predicted N Terminal | Leu 25 |
AA Sequence | Met1-Gln167 |
Molecular Weight | The recombinant cynomolgus PDCD1 consists of 396 amino acids and predicts a molecular mass of 44.5 kDa. |
Purity | Greater than 95% as determined by SDS-PAGE. |
Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
Bioactivity | Please contact us for detailed information |
Formulation | Lyophilized from sterile PBS, pH 7.4. |
Stability | Recombinnat Proteins are stable for up to 1 year from date of receipt at -70°C |
Usage | For Research Use Only |
Storage | Store recombinant protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |