Name: Recombinant Cynomolgus DR6 Protein (His Tag)
Brand: Beta LifeScience
SKU: BLPSN-1659
Availability: InStock

Recombinant Cynomolgus DR6 Protein (His Tag)

Catalog No.: BLPSN-1659

Product Overview

Tag	His
Host Species	Cynomolgus
Accession	XP_005552846.1
Background	TNFRSF21 (death receptor-6, DR6) is an orphan TNF receptor superfamily member and belongs to a subgroup of receptors called death receptors. This type I transmembrane receptor possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is an extensively posttranslationally modified transmembrane protein and that N- and O-glycosylations of amino acids in its extracellular part. DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain, and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis. DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production, suggested that DR6 serves as an important regulatory molecule in T-helper cell activation, and is involved in inflammation and immune regulation. DR6 is expressed ubiquitously with high expression in lymphoid organs, heart, brain and pancreas. Some tumor cells overexpress DR6, typically in conjunction with elevated anti-apoptosis molecules. DR6 may also be involved in tumor cell survival and immune evasion, which is subject to future investigations.
Description	A DNA sequence encoding the cynomolgus TNFRSF21 (XP_005552846.1) (Met1-Leu350) was expressed with a His tag at the C-terminus.
Source	HEK293
Predicted N Terminal	Gln 42
AA Sequence	Met1-Leu350
Molecular Weight	The recombinant cynomolgus TNFRSF21 consists 320 a.a. and predicts a molecular mass of 35 kDa.
Purity	>95% as determined by SDS-PAGE.
Endotoxin	< 1.0 EU per μg protein as determined by the LAL method.
Bioactivity	Measured by its ability to bind with APP-Fc in a functional ELISA.
Formulation	Lyophilized from sterile PBS, pH 7.4..
Stability	The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage	For Research Use Only
Storage	Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.