Native Human Alpha 2 Hs Glycoprotein

Name: Native Human Alpha 2 Hs Glycoprotein
Brand: Beta LifeScience
SKU: BAR-0056P
Price: 825.0 USD
Availability: InStock

Collections: All products, Christmas & new year research sale — 30% off storewide, Native proteins

Price

Size

1mg

Quantity

Submit an inquiry or email sales for a custom bulk quote. Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.

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Product Overview

Description	Native Human Alpha-2-HS-Glycoprotein (AHSC; Fetuin-A) functions as a multifunctional plasma glycoprotein that plays pivotal roles in mineral metabolism, bone remodeling, and the regulation of insulin signaling through its dual capacity to inhibit ectopic calcification and modulate cytokine activity. This hepatocyte-derived protein, which belongs to the cystatin superfamily, operates as a systemic inhibitor of pathological calcification by forming soluble complexes with calcium and phosphate ions to prevent precipitation, while simultaneously serving as a natural antagonist of TGF-β signaling through direct binding to the cytokine and its receptors. Through these mechanisms, fetuin-A not only maintains mineral homeostasis and vascular health but also influences insulin receptor tyrosine kinase activity, inflammatory responses, and macrophage activation, with its plasma concentrations serving as a biomarker for insulin resistance, cardiovascular calcification risk, and overall mortality in chronic kidney disease and systemic inflammatory conditions.
Source	Human Plasma
Form	Lyophilized Powder
Buffer	Lyophilized from 20 mM Tris-HCl, pH 8.0, with 200 mM NaCl
Purity	Greater than 95% as determined by SDS-PAGE.
Molecular Weight	49kDa
Protein Determination	Extinction Coefficient (E) = 0.54 (0.1% at 280 nm, 1 cm pathway)
Storage/Handling	≤ -20 °C

FAQs

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Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.