Recombinant Epidermal Growth Factor (EGF) Proteins
8 products
Epidermal Growth Factor (EGF) plays a central role in cell biology by stimulating cell growth, proliferation, and differentiation through its interaction with the EGF receptor (EGFR). First discovered in the 1960s, EGF has since become one of the most studied growth factors, especially due to its applications in tissue repair and regenerative medicine. At Beta LifeScience, we offer a curated collection of recombinant human EGF proteins to support research in areas like oncology, wound healing, cell therapy, and stem cell biology.
EGF’s biological influence goes far beyond the epidermis. It affects various systems across the body, including the nervous system, gastrointestinal tract, and even the immune response. In scientific studies, human recombinant EGF is frequently used to culture epithelial cells, accelerate tissue repair, and analyze EGFR-related signal transduction. Whether you’re developing targeted therapies or advancing your understanding of cellular behavior, high-purity recombinant EGF proteins are essential for consistent and reproducible results.
In this collection, you’ll find active and GMP-grade EGF recombinant human proteins produced in different host systems, including E. coli, yeast, and mammalian cells. Every protein undergoes stringent testing to ensure high bioactivity and purity, making them reliable tools for a range of experimental protocols.
Key Functions of Recombinant EGF
EGF is a small polypeptide growth factor that triggers downstream cellular processes by binding to its receptor, EGFR, a transmembrane tyrosine kinase. The binding of recombinant human EGF to EGFR initiates a cascade of intracellular signals that promote:
- Cell proliferation and survival
- Wound healing and tissue regeneration
- Angiogenesis
- Embryonic development
- Neural and epithelial maintenance
This makes recombinant EGF a powerful component in tissue engineering, cosmetic development, and cancer biology studies. Researchers often integrate EGF recombinant human protein into cell culture media to improve viability, especially in epithelial and stem cell lines.
Resources
Epidermal Growth Factor (EGF) Proteins Blog Articles
Featured Products
| Cat. No. | Species | Product Description | Host | Structure | Purity | Activity | Features |
|---|---|---|---|---|---|---|---|
| BLPSN-1714 | Human | Human EGF Protein (Fc Tag), Active | Mammalian Cells | P01133 (971-1023aa) | > 90 % | ED50: 0.3-1.5 ng/mL. | SDS-PAGE,Cell Based |
| BLC-08407P | Human | Human Pro-EGF Protein (GST) | E.coli | P01133 (977-1023aa) | > 90 % | Not Test | SDS-PAGE |
| BLC-05995P | Human | Human EGF Protein, Active, GMP | E.Coli | P01133 (971-1023aa) | > 98 % | ED50 is less than 0.1 ng/ml | SDS-PAGE,Cell Based,HPLC |
| BLC-05958P | Human | Human EGF Protein, Active | E.coli | P01133 (971-1023aa) | >95% | ED50: 0.1-0.5 ng/ml | SDS-PAGE |
| BLC-06005P | Human | Human Pro-EGF Protein, Active | E.coli | P01133 (971-1023aa) | >95% | ED50is less than 1 ng/ml | SDS-PAGE,Cell Based,HPLC |
| BLPSN-1712 | Human | Human EGF Protein, Active | E. coli | P01133 (971-1023aa) | ≥ 95 % | ED50: 0.02-0.2ng/ml. | SDS-PAGE,Cell Based,HPLC |
| BL-1779NP | Human | Human EGF Protein, Active | E. coli | P01133 (971-1023aa) | >95% | ED50: 60-450 pg/ml. | SDS-PAGE,Cell Based |
| BLPSN-1717 | Mouse | Mouse EGF Protein (Fc Tag), Active | Mammalian Cells | P01132 (977-1029aa) | > 95 % | ED50: 0.5-3 ng/mL. | SDS-PAGE,Cell Based |
| BLPSN-1716 | Mouse | Mouse EGF Protein, Active | Yeast | P01132 (977-1029aa) | > 95 % | ED50: 30-180 pg/mL. | SDS-PAGE,Cell Based |
| BLC-05925P | Mouse | Mouse Pro-EGF Protein (His), Active | E.coli | P01132 (977-1029aa) | >95% | ED50 is less than 5 ng/ml. | SDS-PAGE,Cell Based |
| BL-0281NP | Mouse | Mouse EGF Protein (C-6His), Active | E. coli | P01132 (977-1029aa) | >95% | ED50: 2-20 ng/ml. | SDS-PAGE,Cell Based |
| BLPSN-1719 | Rat | Rat EGF Protein, Active | E. coli | P07522 (974-1026aa) | > 95 % | ED50: 0.05-0.3ng/mL. | SDS-PAGE,Cell Based |
| BLPSN-1710 | Canine | Canine EGF Protein (His Tag), Active | E. coli | Q9BEA0 (973-1024aa) | ≥ 95 % | EC50: 0.5-3 ng/ml. | SDS-PAGE,Cell Based |
| BLPSN-1709 | Canine | Canine EGF Protein, Active | Yeast | Q9BEA0 (973-1024aa) | > 95 % | ED50: 0.1-0.6 ng/mL. | SDS-PAGE,Cell Based |
Role of EGF in Disease and Therapy
While EGF’s regenerative potential is widely valued, its dysregulation has been linked to multiple diseases, including:
- Cancer: Overexpression of EGFR or persistent activation via human recombinant EGF can lead to uncontrolled cellular growth and tumor progression. This is commonly observed in breast, lung, and colon cancers.
- Fibrosis: EGF has been implicated in tissue remodeling and fibrosis, especially in chronic wound healing scenarios.
- Inflammation: Altered EGF signaling is known to affect immune system modulation and inflammatory response.
Due to these factors, EGF recombinant human protein is a focal point of targeted therapeutic research. EGFR inhibitors, for example, are commonly used in anti-cancer drugs, making the study of recombinant EGF essential for preclinical validation.
Applications of Recombinant Human EGF
Researchers, biotech labs, and pharmaceutical companies rely on recombinant human EGF for applications such as:
- Wound Healing Research: EGF plays a critical role in epithelial regeneration and has shown promise in promoting dermal repair in burns and ulcers.
- Tissue Engineering: In regenerative medicine, human recombinant EGF is used to stimulate stem cell growth and differentiation, helping to create tissue models for transplantation or research.
- Cell Culture Media Supplement: Adding recombinant EGF to serum-free media enhances cell viability and growth, particularly in epithelial and keratinocyte cultures.
- Cancer Signaling Pathways: Studying the interaction between EGF recombinant human protein and EGFR aids in understanding drug resistance mechanisms in cancer treatments.
- Cosmetic and Dermatology Studies: EGF has been explored in formulations for anti-aging and skin regeneration due to its ability to boost collagen production and skin cell turnover.
Why Choose Beta LifeScience Recombinant EGF
Our recombinant EGF proteins are produced with precision and tested rigorously for bioactivity, structural integrity, and purity. Here’s what makes our catalog stand out:
- High Purity (>95%): All proteins are tested via SDS-PAGE and other advanced quality control techniques to ensure minimal contaminants.
- Verified Bioactivity: Each recombinant human EGF product is validated with ED50 assays and cell-based functional tests, giving you consistent results in your experiments.
- Wide Species Range: In addition to EGF recombinant human protein, we offer active EGF variants from mouse, rat, and canine sources to support cross-species studies.
- Multiple Expression Hosts: Choose from proteins expressed in E. coli, yeast, or mammalian systems depending on your application requirements for glycosylation and folding.
- GMP Grade Options: For translational and clinical research needs, GMP-grade recombinant EGF is available to meet regulatory standards.
Related Growth Factor Collections
If your research explores other signaling pathways or regenerative biology models, you may also want to explore:
- Growth Factors: Browse signaling proteins that drive cell division, differentiation, and healing.
- BMP Proteins: Examine the signaling interactions between BMPs and EGF in developmental biology.
- In-Stock Recombinant Proteins: View our full selection of ready-to-ship proteins for urgent experimental timelines.
- Interleukins Collection: Study inflammatory pathways in conjunction with EGF’s regulatory roles in immune responses.
Recombinant human EGF remains a cornerstone of modern biological and medical research. Whether you're modeling cancer progression, optimizing tissue culture conditions, or developing regenerative therapies, our high-performance EGF recombinant human proteins are tailored to help you achieve robust and reproducible outcomes.
At Beta LifeScience, we combine scientific precision with convenience—giving you access to well-characterized human recombinant EGF proteins that meet the demands of innovative research. Every vial you receive has been backed by rigorous validation and manufactured with quality at its core. Ready to elevate your next experiment? Explore our collection of recombinant EGF proteins today.
