Recombinant Rat B7-H6 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0337
Recombinant Rat B7-H6 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0337
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | His |
Host Species | Rat |
Accession | XP_006223356.1 |
Synonym | B7-H6 Natural cytotoxicity triggering receptor 3 ligand 1; B7 homolog 6; B7-H6; NCR3LG1; B7H6 |
Background | Natural cytotoxicity triggering receptor 3 ligand 1(B7-H6) is a glycosylated member of the B7 family of immune costimulatory proteins. Mature human B7-H6 consists of a 238 amino acid (aa) extracellular domain (ECD) that contains one Ig-like V domain and one Ig-like C1 domain, a 21 aa transmembrane segment, and a 171 aa cytoplasmic domain that contains one ITIM, one SH2, and one SH3 motif. Both of the Ig-like domains carry N-linked glycosylation. The Ig-like V domain mediates 1:1 stoichiometric binding of B7-H6 to NKp30 expressed on NK cells. It does not show binding to NKp44, NKp46, or NKG2D. Ligation of NKp30 by B7-H6 induces NK cell activation and target cell cytolysis. B7-H6 is expressed on a wide range of hematopoietic, carcinoma, and melanoma tumor cells, which is consistent with the detection of NKp30 binding sites on many tumors. |
Description | A DNA sequence encoding the rat NCR3LG1 (XP_006223356.1) (Met1-Ser308) was produced with a His tag at the C-terminus. |
Source | HEK293 |
Predicted N Terminal | Met |
AA Sequence | Met1-Ser308 |
Molecular Weight | The recombinant rat NCR3LG1 consists 319 amino acids and predicts a molecular mass of 35.1 kDa. |
Purity | Greater than 95% as determined by SDS-PAGE. |
Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
Bioactivity | Please contact us for detailed information |
Formulation | Lyophilized from sterile PBS, pH 7.4. |
Stability | Recombinnat Proteins are stable for up to 1 year from date of receipt at -70°C |
Usage | For Research Use Only |
Storage | Store recombinant protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |