Recombinant Mouse MDC Protein
Beta LifeScience
SKU/CAT #: BLA-2306P
Recombinant Mouse MDC Protein
Beta LifeScience
SKU/CAT #: BLA-2306P
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Host Species | Mouse |
Accession | O88430 |
Synonym | A 152E5.1 ABCD 1 ABCD1 C C motif chemokine 22 CC chemokine STCP 1 CC chemokine STCP-1 ccl 22 Ccl22 CCL22_HUMAN Chemokine (C C motif) ligand 22 DC/B CK DCBCK Macrophage-derived chemokine MDC MDC(1-69) MDC(7-69) MGC34554 SCYA22 Small inducible cytokine subfamily A (Cys Cys) member 22 Small inducible cytokine subfamily A, member 22 Small-inducible cytokine A22 STCP 1 STCP1 Stimulated T cell chemotactic protein 1 Stimulated T-cell chemotactic protein 1 |
Description | Recombinant Mouse MDC Protein was expressed in Freestyle 293-F cells. It is a Full length protein |
Source | Freestyle 293-F cells |
AA Sequence | GPYGANVEDSICCQDYIRHPLPSRLVKEFFWTSKSCRKPGVVLITVKNRD ICADPRQVWVKKLLHKLS |
Molecular Weight | 8 kDa |
Purity | >97% SDS-PAGE.>97% as determined by HPLC. |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Bioactivity | Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human activated lymphocytes is in a concentration range of 10-100 ng/ml. |
Formulation | Lyophilised |
Stability | The recombinant protein samples are stable for up to 12 months at -80°C |
Reconstitution | See related COA |
Unit Definition | For Research Use Only |
Storage Buffer | Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle. |
Target Details
Target Function | Chemotactic for activated T-lymphocytes. May play an important role in the collaboration of dendritic cells and B-lymphocytes with T-cells in immune responses. |
Subcellular Location | Secreted. |
Protein Families | Intercrine beta (chemokine CC) family |
Database References | |
Tissue Specificity | Expressed by activated splenic B-lymphocytes and dendritic cells. Low expression in lung, thymocytes, lymph node, and unstimulated splenic cells. |
Gene Functions References
- the subset of peritoneal CD11b(+)CD169(+) macrophages increased and CCL22 expression level decreased significantly during the DSS-induced colitis PMID: 28466432
- Intratumoral administration of anti-CCL22 antibody inhibited B16F10 melanoma growth. PMID: 28668835
- this study shows that intravenous injection of apoptotic cells induces a subsequent increase in CCL22 expression and CCR4+ Treg cells, which contribute to the maintenance of immune homeostasis at least partially by splenic CD8alpha+ CD103+ dendritic cells PMID: 26868141
- CCL22-specific antibodies reveal that engagement of two distinct binding domains on CCL22 is required for CCR4-mediated function. PMID: 26683175
- CCL22 was localised mainly on the cell surface and or in the cytoplasm. Within sections of omental milky spot micrometastases, CCR4 was recognised on or in gastric cancer cells, constituent cells milky spots, blood cells and blood endothelial cells PMID: 25245466
- results show that the IL-4/CCL22/CCR4 axis is involved in the migration of Tregs to osteolytic lesion sites, and attenuates development of lesions by inhibiting inflammatory migration and the production of proinflammatory and osteoclastogenic mediators PMID: 25264308
- CCL22 has a role in Treg skin homing to suppress depigmentation PMID: 25634358
- CCL22 is a novel mediator of lung inflammation following hemorrhage and resuscitation PMID: 25136780
- The immunomodulatory properties of CCL22 could be harnessed for prevention of graft rejection and type 1 diabetes as well as other autoimmune disorders. PMID: 25740943
- Data indicate macrophage-derived chemokine CCL22 as an adjuvant could enhance the immune protective effect of NTHi-P6 protein vaccine to an extent. PMID: 25200152
- islet expression of CCL22 recruits Tregs and attenuates autoimmune destruction of beta cell PMID: 21737880
- Data show that the presence of the Ccr4 and Ccl22 transcripts were detected in brain slices. PMID: 21177120
- These results suggest that CCL22 functions to regulate development of experimental autoimmune encephalomyelitis through macrophage chemoattraction and effector function. PMID: 20940325
- role of CCL22 for the recruitment of eosinophils during allergic pleurisy PMID: 12629149
- functionally increased expression during Salmonella enterica serovar Typhimurium infection of dendritic cells PMID: 15731072
- Regulatory elements of the CCL22 gene required to mediate a strong and highly specific expression are included in a 4.1-kb promoter region, with the major elements active in dendritic cells and B cells being located in a small proximal 250-bp region. PMID: 15843561
- CCL22 was selectively upregulated in osteoclast-like cells derived from RAW264.7 cells and mouse bone marrow cells upon stimulation with RANKL (receptor activator of nuclear factor-kappaB ligand). PMID: 16821125
- IgE appears to be capable of stimulating basophils to produce MDC in the absence of a specific Ag, which may contribute to IgE-mediated and/or Th2-predominant allergic inflammation. PMID: 18832724
- When isolated, only natural killer (NK)-containing cellular fractions secrete CCL22, and the same fraction isolated from metastatic Lewis lung carcinoma (LLC)-bearing lungs secrete higher levels. PMID: 19234170
- Mice genetically deficient in CCR4 (the receptor for CCL22) show markedly reduced indoleamine dioxygenase (IDO) expression in MLN-DCs and support the involvement of the CCL22/CCR4 axis in IDO induction. PMID: 19843945