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Recombinant Human LAG-3 Protein (Fc Tag)

Cat No.: BL-0188NP
Description Related products
tag Fc
host species Human
accession P18627
synonym LAG-3 Lymphocyte activation gene 3 protein;LAG3;LAG-3;Protein FDC;CD223
background Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.
description Recombinant Human Lymphocyte Activation Gene 3 Protein is expressed by our Mammalian expression system and the target gene encoding Leu23-Leu450 is expressed with a Fc tag at the C-terminus.
source Human Cells
AA sequence Leu23-Leu450
purity >95% as determined by reducing SDS-PAGE.
endotoxin <0.1 ng/µg (1 EU/µg) as determined by LAL test.
formulation Recombinant Human LAG-3 Protein was lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
reconstitution Dissolve the lyophilized protein in distilled water.
usage For Research Use Only
storage Human LAG-3 protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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