Recombinant Mouse IL-6 Protein, Active

Beta LifeScience SKU/CAT #: BEP-0039

Recombinant Mouse IL-6 Protein, Active

Beta LifeScience SKU/CAT #: BEP-0039
/
Size

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Product Overview

Product Name Recombinant Mouse IL-6 Protein
Target Symbol CSF2
Alternative Names Granulocyte Macrophage Growth Factor, CSF2, Sargramostim, Molgramostim, Colony Stimulating Factor 2, Pluripoietin-a, MGI-IGM, Csfgm
Accession Number P04141
Expression System E. coli.
Molecular Weight 14.6 kDa (predicted)
Sequence Ala18-Glu144, with an N-terminal Met
Purity Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining
Activity Determined by in-house activity assay
Formulation Lyophilized from sterile PBS with Trehalose, pH 7.4
Endotoxin Level Available Upon Request
Shipping Shipped at ambient temperature.
Stability & Storage 12 months from date of receipt at -20°C to -70°C, lyophilized powder. 3 months at -20°C to -70°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw cycles.
Reconstitution Reconstitute at 100 ug/mL in sterile PBS.
Target Function Granulocyte Macrophage Growth Factor (GM-CSF), also known as CSF2, is a cytokine with diverse biological functions, primarily related to immune and inflammatory responses. In addition to a role in maintaining a niche environment for hematopoietic stems cells, GM-CSF stimulates the growth and differentiation of hematopoietic progenitor cells from various lineages including granulocytes (neutrophils, eosinophils, and basophils) and macrophages. The production of GM-CSF by T cells, macrophages, dendritic cells, B cells, eosinophils, and mast cells leads to the differentiation and activation of various immune cells, including macrophages and dendritic cells. Activation of dendritic cells and T cells involving GM-CSF plays a role in the native anti-tumor immune response, which has led to immunotherapies such as chimeric antigen receptor (CAR) T cell therapy. GM-CSF is also involved in enhancement of antibody production by B cells, the Th1 polarized immune response, and tissue repair and remodeling processes. GM-CSF binds a receptor complex composed of the GM-CSF R alpha (CD116) and common beta chain (CD131).
Tissue Specificity Bone marrow stromal cells, lymph node, spleen, vascular endothelial cells, respiratory and gastrointestinal epithelial cells, and fibroblasts.
Cellular Localization Secreted protein
Involvement In Disease Dysregulation of GM-CSF production is implicated in autoimmune disorders (rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease), cancer tumor progression, cancer immune evasion, leukemia, myelodysplastic syndromes, pulmonary alveolar proteinosis (PAP), allergic inflammation (asthma, atopic dermatitis) and neuroinflammatory processes in Alzheimer’s disease and Parkinson’s disease.

FAQs

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Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.

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