Recombinant Human UBE2L6 (UBCH8) Protein

Beta LifeScience SKU/CAT #: BL-0113SG
Recombinant Human UBE2L6 (UBCH8) Protein

Recombinant Human UBE2L6 (UBCH8) Protein

Beta LifeScience SKU/CAT #: BL-0113SG
Catalog No.: BL-0113SG

Product Overview

Tag His
Host Species Human
Accession NM_004223
Synonym RIG-B, UBCH8
Background UBE2L6 (UBCH8) or ubiquitin-conjugating enzyme E2L 6 is a member of the E2 ubiquitin-conjugating enzyme family which is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) and the selective physical interaction between E2 and E3 enzymes forms the basis of specificity for functionally distinct E2-E3 combinations (1).UBE2L6 and the ubiquitin-ligase SIAH1 physically interact with and target FLT3-ITD for proteasomal degradation (2).
Description Recombinant full length human UBE2L6 (UBCH8) was produced in E. coli system using a N-terminual His tag. This protein is purified with our unique purification methods.
Source E.coli
AA Sequence Full Length
Molecular Weight ~17 kDa
Purity For specific purity information on a given lot, see related COA.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Active
Formulation Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
Stability The recombinant protein is stable for up to 12 months at -70°C
Usage For Research Use Only
Storage Recombinant Human UBE2L6 (UBCH8) Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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