Recombinant Human UBE2L6 (UBCH8) Protein
Beta LifeScience
SKU/CAT #: BL-0113SG
Recombinant Human UBE2L6 (UBCH8) Protein
Beta LifeScience
SKU/CAT #: BL-0113SG
Catalog No.: BL-0113SG
Product Overview
| Tag | His |
| Host Species | Human |
| Accession | NM_004223 |
| Synonym | RIG-B, UBCH8 |
| Background | UBE2L6 (UBCH8) or ubiquitin-conjugating enzyme E2L 6 is a member of the E2 ubiquitin-conjugating enzyme family which is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) and the selective physical interaction between E2 and E3 enzymes forms the basis of specificity for functionally distinct E2-E3 combinations (1).UBE2L6 and the ubiquitin-ligase SIAH1 physically interact with and target FLT3-ITD for proteasomal degradation (2). |
| Description | Recombinant full length human UBE2L6 (UBCH8) was produced in E. coli system using a N-terminual His tag. This protein is purified with our unique purification methods. |
| Source | E.coli |
| AA Sequence | Full Length |
| Molecular Weight | ~17 kDa |
| Purity | For specific purity information on a given lot, see related COA. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Active |
| Formulation | Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol. |
| Stability | The recombinant protein is stable for up to 12 months at -70°C |
| Usage | For Research Use Only |
| Storage | Recombinant Human UBE2L6 (UBCH8) Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
