Recombinant Human UBE2G2 Protein (GST Tag)
Beta LifeScience
SKU/CAT #: BL-0267NP
Recombinant Human UBE2G2 Protein (GST Tag)
Beta LifeScience
SKU/CAT #: BL-0267NP
Catalog No.: BL-0267NP
Product Overview
| Tag | GST |
| Host Species | Human |
| Accession | P60604 |
| Synonym | UBE2G2 Ubiquitin-Conjugating Enzyme E2 G2; Ubiquitin Carrier Protein G2; Ubiquitin-Protein Ligase G2; UBE2G2 |
| Background | Ubiquitin-Conjugating Enzyme E2 G2 (UBE2G2) is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation, which belong to the ubiquitin-conjugating enzyme family. It shares 60% and 100% sequence identity with S.cerevisiae Ubc7 and mouse respectively. The UBE2G2 enzyme and the GP78 E3 ligase are active components of endoplasmic reticulum-associated degradation pathway which is essential for the degradation of misfolded ER proteins. The mechanism of K48-linked poly-ubiquitination by UBE2G2/GP78 appears to involve the transfer of preassembled Ub chains from UBE2G2 to lysine residues in a substrate. The E2 and E3 enzymes form a large hetero-oligomer which brings multiple UBE2G2 molecules into close proximity which allows for Ub transfer between neighboring E2s. |
| Description | Recombinant Human Ubiquitin-Conjugating Enzyme E2 G2 is expressed by our E.coli expression system and the target gene encoding Met1-Leu165 is expressed with a GST tag at the N-terminus. |
| Source | E.coli |
| AA Sequence | Met1-Leu165 |
| Purity | >95% as determined by reducing SDS-PAGE. |
| Endotoxin | <0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Recombinant Human UBE2G2 Protein was supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 2mM DTT, 10% Glycerol, pH 7.5. |
| Usage | For Research Use Only |
| Storage | Human UBE2G2 protein should be stored at < -20°C, stable for 6 months after receipt.Please minimize freeze-thaw cycles. |
