Recombinant Human UBE2G2 Protein (GST Tag)

Beta LifeScience SKU/CAT #: BL-0267NP
Recombinant Human UBE2G2 Protein (GST Tag)

Recombinant Human UBE2G2 Protein (GST Tag)

Beta LifeScience SKU/CAT #: BL-0267NP
Catalog No.: BL-0267NP

Product Overview

Tag GST
Host Species Human
Accession P60604
Synonym UBE2G2 Ubiquitin-Conjugating Enzyme E2 G2; Ubiquitin Carrier Protein G2; Ubiquitin-Protein Ligase G2; UBE2G2
Background Ubiquitin-Conjugating Enzyme E2 G2 (UBE2G2) is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation, which belong to the ubiquitin-conjugating enzyme family. It shares 60% and 100% sequence identity with S.cerevisiae Ubc7 and mouse respectively. The UBE2G2 enzyme and the GP78 E3 ligase are active components of endoplasmic reticulum-associated degradation pathway which is essential for the degradation of misfolded ER proteins. The mechanism of K48-linked poly-ubiquitination by UBE2G2/GP78 appears to involve the transfer of preassembled Ub chains from UBE2G2 to lysine residues in a substrate. The E2 and E3 enzymes form a large hetero-oligomer which brings multiple UBE2G2 molecules into close proximity which allows for Ub transfer between neighboring E2s.
Description Recombinant Human Ubiquitin-Conjugating Enzyme E2 G2 is expressed by our E.coli expression system and the target gene encoding Met1-Leu165 is expressed with a GST tag at the N-terminus.
Source E.coli
AA Sequence Met1-Leu165
Purity >95% as determined by reducing SDS-PAGE.
Endotoxin <0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Recombinant Human UBE2G2 Protein was supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 2mM DTT, 10% Glycerol, pH 7.5.
Usage For Research Use Only
Storage Human UBE2G2 protein should be stored at < -20°C, stable for 6 months after receipt.Please minimize freeze-thaw cycles.
Recently viewed