Recombinant Human TSLP Protein
Beta LifeScience
SKU/CAT #: BL-1719SG
Recombinant Human TSLP Protein
Beta LifeScience
SKU/CAT #: BL-1719SG
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | N/A |
Host Species | Human |
Accession | Q969D9 |
Synonym | Thymic stromal lymphopoietin, TSLPRecombinant Human Thymic Stromal Lymphopoietin (TSLP) |
Background | TSLP is a hemopoietic protein that was initially identified from mouse thymic stromal cell line that promoted the development of B cells. TSLP overlaps biological activities with IL-7 and can co-stimulate growth of thymocytes and mature T cells alongside supporting lymphopoiesis. Human TSLP shares approximately 43% amino acid sequence identity with mouse TSLP. Human TSLP has been detected in many tissues although the highest level of expression has been found in the heart, liver, testis and prostate. TSLP signals through a heterodimeric receptor complex that consists of IL-7R-alpha and the TSLP-R. |
Description | Recombinant Human TSLP was produced in E. coli. This protein is purified with our unique purification methods. |
Source | E.coli |
Molecular Weight | 15.0 kDa |
Purity | For specific purity information on a given lot, see related COA. |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Formulation | Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol. |
Stability | The recombinant protein is stable for up to 12 months at -70°C |
Usage | For Research Use Only |
Storage | Recombinant Human TSLP Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Target Details
Target Function | Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.; May act as an antimicrobial peptide in the oral cavity and on the skin. |
Subcellular Location | Secreted. |
Database References | HGNC: 30743 OMIM: 607003 KEGG: hsa:85480 STRING: 9606.ENSP00000339804 UniGene: PMID: 28368013 |