Recombinant Human TPM3-ROS1 Protein
Beta LifeScience
SKU/CAT #: BL-0347SG
Recombinant Human TPM3-ROS1 Protein
Beta LifeScience
SKU/CAT #: BL-0347SG
Catalog No.: BL-0347SG
Product Overview
| Tag | GST |
| Host Species | Human |
| Accession | NM_152263NM_002944 |
| Synonym | TPM3: CAPM1; CFTD; hscp30; NEM1; OK/SW-cl.5; TM-5; TM3; TM30; TM30nm; TM5; TPMsk3; TRKROS1: c-ros-1; MCF3; ROS |
| Background | TPM3 is a member of the tropomyosin family of actin-binding proteins which are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in TPM3 gene result in autosomal dominant nemaline myopathy and other muscle disorders (1). TPM3 gene locus is involved in translocations with other loci including c-ros oncogene 1 (ROS1) which result in the formation of the TPM3-ROS1 fusion protein that act as an oncogene. TPM3-ROS1 fusion gene product has been detected in lung adenocarcinoma is higher in lung adenocarcinoma with wild-type EGFR (2). |
| Description | Recombinant human fusion protein TPM3 (1-258)-ROS1 (1881-end) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods. |
| Source | Sf9 insect cells |
| AA Sequence | 1881a.a.-end |
| Molecular Weight | 108 kDa |
| Purity | For specific purity information on a given lot, see related COA. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Active |
| Formulation | Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol. |
| Stability | The recombinant protein is stable for up to 12 months at -70°C |
| Usage | For Research Use Only |
| Storage | Recombinant Human TPM3-ROS1 Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
