Recombinant Human TLT-1 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-4551
Recombinant Human TLT-1 Protein (His Tag)

Recombinant Human TLT-1 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-4551
Catalog No.: BLPSN-4551

Product Overview

Tag His
Host Species Human
Accession Q86YW5
Synonym dJ238O23.3, GLTL1825, MGC119173, PRO3438, TLT-1, TLT1, UNQ1825/PRO3438
Background Trem-like transcript 1 protein, also known as Triggering receptor expressed on myeloid cells-like protein 1, TREML1 and TLT-1, is a cytoplasm and single-pass type I membrane protein. TREML1 / TLT-1 is expressed exclusively in platelets and megakaryocytes (MKs) and that its expression is up-regulated dramatically upon platelet activation. It is a receptor that may play a role in the innate and adaptive immune response. TREML1 / TLT-1 contains the characteristic single V-set immunoglobulin (Ig) domain, its longer cytoplasmic tail is composed of both a proline-rich region and an immune receptor tyrosine-based inhibitory motif, the latter known to be used for interactions with protein tyrosine phosphatases. The triggering receptors expressed on myeloid cells (TREMs) have drawn considerable attention due to their ability to activate multiple cell types within the innate immune system, including neutrophils, monocyte / macrophages, and dendritic cells, via their association with DAP12. TREML1 / TLT-1 is prepackaged, along with CD62P, into both MK and platelet alpha-granules. Differences in thrombin-induced redistribution of CD62P and TREML1 indicate that TREML1 is not simply cargo of alpha-granules but may instead regulate granule construction or dispersal. TREML1 / TLT-1 does not function to inhibit members of the TREM family but instead may play a role in maintaining vascular hemostasis and regulating coagulation and inflammation at sites of injury.
Description A DNA sequence encoding the human TREML1 isoform 1 (Q86YW5-1) extracellular domain (Met 1-Pro 162) was expressed, with a His tag at the C-terminus.
Source HEK293
Predicted N Terminal Gln 16
AA Sequence Met 1-Pro 162
Molecular Weight The recombinant human TREML1 consists of 158 a.a. and predictes a molecular mass of 17.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhTREML1 is approximately 24 kDa.
Purity >90% as determined by SDS-PAGE
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.4.
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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