Recombinant Human TFG-ALK (Tex5Aex20) Protein

Beta LifeScience SKU/CAT #: BL-0253SG
Recombinant Human TFG-ALK (Tex5Aex20) Protein

Recombinant Human TFG-ALK (Tex5Aex20) Protein

Beta LifeScience SKU/CAT #: BL-0253SG
Catalog No.: BL-0253SG

Product Overview

Tag GST
Host Species Human
Accession NM_001195478NM_004304
Synonym TFG: HMSNP; SPG57; TF6ALK: ALK (Ki-1), CD246
Background Anaplastic large cell lymphomas are associated with chromosomal aberrations involving the anaplastic lymphoma kinase (ALK) gene, resulting in the expression of novel chimeric ALK proteins with transforming properties. In most of these tumors, the t(2;5)(p23;q35) generates the NPM-ALK fusion gene. Genes other than NPM have been demonstrated to fuse to the ALK gene. Two different ALK rearrangements involving the TRK-fused gene (TFG) in which the same portion of ALK was fused to different length fragments of the 5' TFG region. These two rearrangements encoded chimeric proteins of 85 kd (TFG-ALK(S)) and 97 kd (TFG-ALK(L)), respectively. TFG can provide an alternative to NPM as a fusion partner responsible for activation of the ALK and the pathogenesis of ALCL.
Description Recombinant human fusion TFG (1-193)-ALK (1058-end) protein was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.
Source Sf9 insect cells
AA Sequence 1058a.a.-end
Molecular Weight ~115 kDa
Purity For specific purity information on a given lot, see related COA.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Active
Formulation Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
Stability The recombinant protein is stable for up to 12 months at -70°C
Usage For Research Use Only
Storage Recombinant Human TFG-ALK (Tex5Aex20) Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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