Human SARM1 (Nad(+) Hydrolase Sarm1) - Recombinant Protein
Beta LifeScience
SKU/CAT #: BLT-08031P
SDS-PAGE analysis of Human SARM1 (Nad(+) Hydrolase Sarm1) - Recombinant Protein, CAT# BLT-08031P, showing >90% purity under 15% SDS-PAGE (Reduced)
Human SARM1 (Nad(+) Hydrolase Sarm1) - Recombinant Protein
Beta LifeScience
SKU/CAT #: BLT-08031P
Regular price
$69500
$695.00
Sale price$55600
$556.00Save $139
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Quantity Pricing
| Pack Size | Price (USD) |
|---|---|
| 500 µg | $1,206.00 Original price: |
| 1 mg | $2,284.00 Original price: |
For direct online orders, quantity pricing will be displayed in cart when you add 5x100ug or 10x100ug
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Product Overview
| Product Name | Recombinant Human Sterile Alpha Motif Domain Containing 2 (SaMD2/SARM1) Protein |
| Product Overview | This recombinant human Sterile Alpha Motif Domain Containing 2 (SaMD2/SARM1) protein includes amino acids 387-548aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in PBSprior to lyophilization. |
| Target Uniprot Id | Q6SZW1 |
| Recommended Name | NAD(+) hydrolase SARM1 |
| Gene Name | SARM1 |
| Synonyms | SARM1; Sterile Alpha And TIR Motif Containing 1; Sterile alpha and Armadillo repeat protein; Tir-1 h |
| Species | Human |
| Predicted Molecular Mass | 33 kDa |
| Expression System | E.coli |
| Expression Range | 387-548aa |
| Tag | N-6His+SUMO |
| Purity | >90% |
| Formulation | Lyophilized |
| Buffer | PBS |
| Storage Condition | 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction | Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications | Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area | Cell Biology |
| Target Function | NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction. Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules. Can activate neuronal cell death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38. |
| Subcellular Location | Cytoplasm. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse. Mitochondrion. |
| Tissue Specificity | Predominantly expressed in brain, kidney and liver. Expressed at lower level in placenta. |
