Name: Recombinant Human ROR1 Protein (Fc Tag)
Brand: Beta LifeScience
SKU: BL-0204NP
Availability: InStock

Catalog No.: BL-0204NP

Product Overview

Tag	Fc
Host Species	Human
Accession	Q01973
Synonym	ROR1 neurotrophic tyrosine kinase receptor-related 1; receptor tyrosine kinase-like orphan receptor 1; ROR1;tyrosine-protein kinase transmembrane receptor ROR1
Background	ROR1ï¼Œalso known as Neurotrophic tyrosine kinase, receptor-related 1, belongs to the ROR subfamily of Tyr protein kinase family,a protein kinase superfamily. It has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Human ROR1 is a type I transmembrane protein with 937 amino acids (aa) in length. It contains a 29 aa signal sequence, a 377 aa extracellular domain (ECD), a 21 aa transmembrane segment, and a 510 aa cytoplasmic region. Human ROR1 shares 97% and 58% aa sequence identity with mouse ROR1 and human ROR2, respectively. ROR1 may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling. ROR1 expressed strongly in human heart, lung and kidney, but weakly in the CNS. Its Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.
Description	Recombinant Human Inactive tyrosine-protein kinase transmembrane receptor ROR1 is expressed by our Mammalian expression system and the target gene encoding Gln30-Glu403 is expressed with a Fc tag at the C-terminus.
Source	Human Cells
AA Sequence	Gln30-Glu403
Purity	>95% as determined by reducing SDS-PAGE.
Endotoxin	<0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Recombinant Human ROR1 Protein was lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution	Dissolve the lyophilized protein in distilled water.
Usage	For Research Use Only
Storage	Human ROR1 protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.