Recombinant Human Ras-Related Protein Rab-6A (RAB6A) Protein (His-SUMO)
Beta LifeScience
SKU/CAT #: BLC-10192P

Greater than 90% as determined by SDS-PAGE.
Recombinant Human Ras-Related Protein Rab-6A (RAB6A) Protein (His-SUMO)
Beta LifeScience
SKU/CAT #: BLC-10192P
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Description | Recombinant Human Ras-Related Protein Rab-6A (RAB6A) Protein (His-SUMO) is produced by our E.coli expression system. This is a full length protein. |
Purity | Greater than 90% as determined by SDS-PAGE. |
Uniprotkb | P20340 |
Target Symbol | RAB6A |
Synonyms | GTP binding protein RAB6A'; GTP binding protein RAB6B; Oncogene RAB6; Rab 6; Rab GTPase; Rab-6; RAB6; RAB6 member RAS oncogene family; RAB6A; RAB6A member RAS oncogene family ; Rab6A variant 3; RAB6A'; RAB6A_HUMAN; RAB6B; Ras related protein Rab 6A; Ras-related protein Rab-6A; RCO4 3 |
Species | Homo sapiens (Human) |
Expression System | E.coli |
Tag | N-6His-SUMO |
Target Protein Sequence | STGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIIMLVGNKTDLADKRQVSIEEGERKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMESTQDRSREDMIDIKLEKPQEQPVSEGGCSC |
Expression Range | 2-208aa |
Protein Length | Full Length of Mature Protein |
Mol. Weight | 39.5kDa |
Research Area | Transport |
Form | Liquid or Lyophilized powder |
Buffer | Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
Reconstitution | Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
Storage | 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Target Details
Target Function | Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Involved in COPI-independent retrograde transport from the Golgi to the ER. |
Subcellular Location | Golgi apparatus membrane; Lipid-anchor.; [Isoform 1]: Golgi apparatus membrane; Lipid-anchor.; [Isoform 2]: Golgi apparatus membrane; Lipid-anchor. |
Protein Families | Small GTPase superfamily, Rab family |
Database References | |
Tissue Specificity | Ubiquitous. |
Gene Functions References
- Ectopic expression of an N-terminal-truncated ARHGEF10 mutant led to the generation of large vesicle-like structures containing both Rab6 and Rab8. PMID: 27550519
- Rab6A binding to KIF1C's motor domain represents an entirely new mode of regulation for a kinesin motor, and likely has important consequences for KIF1C's cellular functions. PMID: 25821985
- GORAB missense mutation disrupt RAB6 protein binding in genetic skin diseases. PMID: 26000619
- several analyses of vesicular transport demonstrated that Rab6A and BICD2 play crucial roles in Golgi tubule fusion with the endoplasmic reticulum (ER) in brefeldin A (BFA)-treated cells PMID: 25962623
- Data suggest that miR-5100 promotes tumor growth by facilitating the G1/S transition and targeting Rab6. PMID: 25754817
- Data indicate that myosin Va interacted with multiple new Rab subfamilies including Rab6, Rab14 and Rab39B. PMID: 24006491
- Mint1 826 bridges APP to the small GTPase PMID: 23737971
- The presence of an active pool of Rab6 within host cells early during infection is required to support efficient intracellular growth of L. pneumophila. PMID: 23569112
- Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase. PMID: 23091056
- GTP-bound form of Rab6 promotes retrograde trafficking of cav-2 from the Golgi to ER PMID: 22607032
- the crystal structure of the human Rab6A'(Q72L) mutant form at 1.9A resolution is reported. PMID: 22750005
- Rab6 modulates the unfolded protein response (UPR), increased levels inhibit whereas decreased levels augment UPR induction. PMID: 22124028
- Electron tomography reveals Rab6 is essential to the trafficking of trans-Golgi clathrin and COPI-coated vesicles and the maintenance of Golgi cisternal number PMID: 22335553
- Rab6 is required for Rab8A association with exocytotic vesicles. PMID: 21596566
- In contrast to wild-type R6IP1-Rab6 crystals, which took several weeks to grow to full size, the engineered R6IP1 (RPdel)-Rab6 crystals could be grown in a matter of days PMID: 21543860
- The authors found that the small GTPase Rab6 also interacts indirectly with cytomegalovirus pp150 through its interaction with Bicaudal D1. PMID: 21411515
- Data show that Rab6, a Golgi-associated Rab, forms a complex with myosin II, contributes to its localization at the Golgi complex and, unexpectedly, controls the fission of Rab6 vesicles. PMID: 20562865
- recombinant antibodies specific to the GTP-bound conformation of Rab6 were generated and used to locate Rab6; Rab6 was in its GTP-bound conformation on the Golgi apparatus and transport intermediates PMID: 12738866
- Rab6A and Rab6A' regulate microtubule-dependent recycling at the trans-Golgi network PMID: 15483056
- 10 genes were down-regulated following treatment of the T-ALL cells with 0.15 and 1.5 microg/mL of metal ores at 72 h. GTP binding activity, RaB small monomeric GTPase activity, protein transporter activity. PMID: 15747776
- Results show the crystal structure of the GTPase Rab6A in the GTP bound form. PMID: 16332443
- Rab6A' likely regulates the dynamics of the dynein/dynactin complex at the kinetochores and consequently the inactivation of the Mad2-spindle checkpoint. PMID: 16395330
- Results show that Rab6A and Rab6A' perform different functions within the cell and suggests a novel role for Rab6A' as the major Rab6 isoform regulating previously described Rab6-dependent transport pathways. PMID: 16536738
- role of the Rab6 isoforms in retrograde transport of ricin using both oligo- and vector-based RNAi assays PMID: 16683916
- a highly significant correlation between the Rab6 and the UPR marker BiP in Alzheimer disease brains. PMID: 17573808
- These data demonstrate that although Rab6 is not essential for secretion, it controls the organization of exocytosis within the cellular space. PMID: 17681140
- Rab6 regulates distinct Golgi trafficking pathways involving two separate protein complexes: ZW10/RINT-1 and COG. PMID: 17699596
- DYNLRB1 specifically interacts with all three Rab6 isoforms and co-localises at the Golgi. PMID: 18044744
- Data show that iPLA(1)gamma is a novel membrane transport factor that contributes to a specific Golgi-to-ER retrograde pathway distinct from presently characterized COPI- and Rab6-dependent pathways. PMID: 19632984
- Study demonstrates that Golgi recruitment of endogenous GCC185 does not involve Rab6A/A' and Arl1. PMID: 19703403