Name: Recombinant Human PTPN6 (SHP1) Protein
Brand: Beta LifeScience
SKU: BL-0200SG
Availability: InStock

Catalog No.: BL-0200SG

Tag	GST
Host Species	Human
Accession	NM_080548
Synonym	SHP1; SHP-1; HCP; HCPH; HPTP1C; PTP-1C; SHP-1L; SH-PTP1
Background	PTPN6 gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells (1). The noncatalytic N-terminus of this PTP can interact with MAP kinases and negatively regulates ERK2 and p38 MAP-kinases activity (2). The PTPN6 was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway.
Description	Recombinant full length human PTPN6 was produced in E. coli, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.
Source	E.coli
AA Sequence	Full Length
Molecular Weight	~93 kDa
Purity	For specific purity information on a given lot, see related COA.
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity	Active
Formulation	Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
Stability	The recombinant protein is stable for up to 12 months at -70°C
Usage	For Research Use Only
Storage	Recombinant Human PTPN6 (SHP1) Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.