Recombinant Human MKK4 Protein

Beta LifeScience SKU/CAT #: BL-0147SG
Recombinant Human MKK4 Protein

Recombinant Human MKK4 Protein

Beta LifeScience SKU/CAT #: BL-0147SG
Catalog No.: BL-0147SG

Product Overview

Tag His
Host Species Human
Accession NM_003010
Synonym MAP2K4, JNKK, MEK4, SEK1, JNKK1, SERK1, MAPKK4, PRKMK4
Background MKK4 is a member of the mitogen-activated protein kinase family and is involved in the stress-activated protein kinase pathway where it phosphorylates c-Jun NH2-terminal kinase (1). MKK4 is part of a signaling system that is stimulated in the presence of stress to the cell (including chemotherapy), and it controls differentiation and programmed cell death (apoptosis). MKK4 is central component of signal transduction pathways induced by mitogens and stresses. MKK4 genetic inactivation has been observed in a subset of pancreatic carcinomas, implicating deregulation of the stress-activated protein kinase pathway in pancreatic carcinogenesis (2).
Description Recombinant human full-length MKK4 was produced by baculovirus in Sf9 insect cells, fused with a His tag at N-terminus.
Source Sf9 insect cells
AA Sequence Full Length
Molecular Weight ~46 kDa
Purity For specific purity information on a given lot, see related COA.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Active
Formulation Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
Stability The recombinant protein is stable for up to 12 months at -70°C
Usage For Research Use Only
Storage Recombinant Human MKK4 Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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