Recombinant Human MKK4 Protein
Beta LifeScience
SKU/CAT #: BL-0147SG
Recombinant Human MKK4 Protein
Beta LifeScience
SKU/CAT #: BL-0147SG
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | His |
Host Species | Human |
Accession | NM_003010 |
Synonym | MAP2K4, JNKK, MEK4, SEK1, JNKK1, SERK1, MAPKK4, PRKMK4 |
Background | MKK4 is a member of the mitogen-activated protein kinase family and is involved in the stress-activated protein kinase pathway where it phosphorylates c-Jun NH2-terminal kinase (1). MKK4 is part of a signaling system that is stimulated in the presence of stress to the cell (including chemotherapy), and it controls differentiation and programmed cell death (apoptosis). MKK4 is central component of signal transduction pathways induced by mitogens and stresses. MKK4 genetic inactivation has been observed in a subset of pancreatic carcinomas, implicating deregulation of the stress-activated protein kinase pathway in pancreatic carcinogenesis (2). |
Description | Recombinant human full-length MKK4 was produced by baculovirus in Sf9 insect cells, fused with a His tag at N-terminus. |
Source | Sf9 insect cells |
AA Sequence | Full Length |
Molecular Weight | ~46 kDa |
Purity | For specific purity information on a given lot, see related COA. |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Bioactivity | Active |
Formulation | Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol. |
Stability | The recombinant protein is stable for up to 12 months at -70°C |
Usage | For Research Use Only |
Storage | Recombinant Human MKK4 Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |