Recombinant Human LIF Protein, Active

Beta LifeScience SKU/CAT #: BEP-0042

Recombinant Human LIF Protein, Active

Beta LifeScience SKU/CAT #: BEP-0042
/
Size

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Product Overview

Product Name Recombinant Human LIF Protein
Target Symbol LIF
Alternative Names Leukemia Inhibitory Factor, Differentiation Inhibitory Activity, Cholinergic Differentiation Factor, Differentiation-Stimulating Factor, Hepatocyte-Stimulating Factor III, Differentiation-Inducing Factor, Melanoma-Derived LPL Inhibitor, D Factor, Emfilermin, HILDA, CDF, DIA, MLPLI
Accession Number P15018
Expression System E. coli.
Molecular Weight 19.7 kDa
Sequence Ser23-Phe202
Purity Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining
Activity Determined by in-house activity assay
Formulation Lyophilized from sterile PBS with Trehalose, pH 7.4
Endotoxin Level Available Upon Request
Shipping Shipped at ambient temperature.
Stability & Storage 12 months from date of receipt at -20°C to -70°C, lyophilized powder. 3 months at -20°C to -70°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw cycles.
Reconstitution Reconstitute at 100 ug/mL in sterile PBS.
Target Function LIF (Leukemia Inhibitory Factor) is a protein that plays multiple roles across regulation of stem cell differentiation, immune response, reproductive function and neuroprotection. LIF is typically associated with the maintenance of pluripotency in embryonic stem cells in cell culture. LIF production by CD4 T cells and Regulatory (Treg) Cells have been shown to suppress Th17 differentiation. Likewise, LIF expressed by tumors have an immunosuppressive effect. In uterine tissues, LIF facilitates embryo attachment to endometrial tissue. LIF downregulates inflammation and promotes the neuroprotective response during injury of neurons, thereby limiting neurodegeneration. LIF signaling occurs by binding to LIF Receptor (LIFR/CD118) heterodimerized to gp130 (CD130).
Tissue Specificity LIF expression has been identified in brain (astrocytes, microglia), neurons, liver, skeletal muscle tissue, endometrium, thymus and lung.
Cellular Localization Secreted protein
Involvement In Disease Dysregulation of LIF has been associated with endometriosis, ectopic pregnancy, rheumatoid arthritis, inflammatory bowel disease (IBD), asthma, multiple sclerosis (MS), Alzheimer’s disease, Parkinson’s disease, myeloid leukemia, and cancers (breast cancer, prostate cancer, pancreatic, ovarian cancer).

FAQs

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Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.

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