Recombinant Human LAG-3 Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-3112
Recombinant Human LAG-3 Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-3112
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | Fc |
Host Species | Human |
Accession | NP_002277.4 |
Synonym | LAG-3 Lymphocyte activation gene 3 protein;LAG3;LAG-3;Protein FDC;CD223 |
Background | Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4. |
Description | A DNA sequence encoding the human LAG3 (NP_002277.4) (Met1-Leu450) was produced with the Fc region of mouse IgG1 at the C-terminus. |
Source | HEK293 |
Predicted N Terminal | Val 29 |
AA Sequence | Met1-Leu450 |
Molecular Weight | The recombinant human LAG3 consists of 656 amino acids and predicts a molecular mass of 72 kDa. |
Purity | Greater than (81.3+10.1)% as determined by SDS-PAGE. |
Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
Bioactivity | Please contact us for detailed information |
Formulation | Lyophilized from sterile PBS, pH 7.4. |
Stability | Recombinnat Proteins are stable for up to 1 year from date of receipt at -70°C |
Usage | For Research Use Only |
Storage | Store recombinant protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |