Recombinant Human KIR2DL3 Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BL-0156NP
Recombinant Human KIR2DL3 Protein (Fc Tag)

Recombinant Human KIR2DL3 Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BL-0156NP
Catalog No.: BL-0156NP

Product Overview

Tag Fc
Host Species Human
Accession P43628
Synonym KIR2DL3 Killer cell immunoglobulin-like receptor 2DL3; KIR2DL3; CD158b2; NKAT2; CD158 antigen-like family member B2; KIR-023GB; Killer inhibitory receptor cl 2-3; MHC class I NK cell receptor; NKAT-2; p58 NK receptor CL-6
Background Killer-Cell Immunoglobulin-Like Receptors (KIRs) are important cells of the immune system. KIRs are a family of Natural Killer (NK) Cells surface glycoproteins. KIRs control the killing function of these cells by interacting with MHC class I molecules. This interaction allows KIRs to identify virally infected cells or tumor cells by the distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory, their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. KIR2DL3 is an inhibitory Killer Cell Ig-like Receptor. KIR2DL3 recognizes class I MHC molecules (HLA-Cw1, -Cw3, -Cw7, and Cw8). KIR2DL3 inhibits the activity of NK cells thus preventing cell lysis.
Description Recombinant Human killer cell immunoglobulin-like receptor 2DL3 is expressed by our Mammalian expression system and the target gene encoding His22-His245 is expressed with a Fc tag at the C-terminus.
Source Human Cells
AA Sequence His22-His245
Purity >95% as determined by reducing SDS-PAGE.
Endotoxin <0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Recombinant Human KIR2DL3 Protein was lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Dissolve the lyophilized protein in distilled water.
Usage For Research Use Only
Storage Human KIR2DL3 protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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