Recombinant Human KGF/FGF-7 Protein, Active, Low Endotoxin

Beta LifeScience SKU/CAT #: BEP-0016UL
Recombinant Human KGF/FGF-7 (2 ug/lane) on SDSPAGE under reducing (R) conditions. The gel was stained using Coomassie® Blue showing a major band at 19 kDa and purity greater than >97%.
Recombinant Human KGF/FGF-7 (2 ug/lane) on SDSPAGE under reducing (R) conditions. The gel was stained using Coomassie® Blue showing a major band at 19 kDa and purity greater than >97%.

Recombinant Human KGF/FGF-7 Protein, Active, Low Endotoxin

Beta LifeScience SKU/CAT #: BEP-0016UL
/
Size

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Product Overview

Product Name Recombinant Human KGF/FGF-7 Protein
Target Symbol FGF7
Alternative Names Keratinocyte Growth Factor, Fibroblast Growth Factor 7, KGF, FGF7, Heparin-Binding Growth Factor 7, HBGF-7
Accession Number P21781
Expression System E.Coli.
Molecular Weight 19 kDa (monomer, predicted)
Sequence Cys32-Thr194, with an N-terminal Met
Purity >97% by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining
Activity Determined by a cell proliferation assay using 4MBr-5 rhesus monkey cells. The ED50 for this effect is typically < 3 ng/mL.
Formulation Lyophilized from sterile PBS with Trehalose, pH 7.4
Endotoxin Level <0.001 EU/1ug of the protein as determined by the LAL method.
Shipping Shipped at ambient temperature.
Stability & Storage 12 months from date of receipt at -20°C to -70°C, lyophilized powder. 3 months at -20°C to -70°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw cycles.
Reconstitution Reconstitute at 100 ug/mL in sterile PBS.
Target Function Keratinocyte growth factor (KGF), also known as fibroblast growth factor 7 (FGF-7) plays a role in embryonic development, cell proliferation, tissue repair, branching morphogenesis, and tumor progression. KGF is primarily expressed in mesenchymal cells, specifically in tissues where epithelial-mesenchymal interactions occur. As such, KGF activity is mainly exhibited on epithelial cells, particularly keratinocytes, by influencing the repair and regeneration of damaged epithelial tissues, facilitating wound healing processes and promoting pathways to protect epithelial cells from UV radiation and toxins. Additionally, KGF is involved in the development and maintenance of hair follicles, promoting hair growth. In cell culture, KGF has efficacy in the differentiation of pluripotent stem cells (PSCs) toward thymic epithelial cells and in the culture of 3-D organoids. The receptor KGF is FGFR2IIIb.
Tissue Specificity KGF has been detected in mesenchymal cells in skin, lung, intestine, salivary glands, and bladder.
Cellular Localization Secreted protein
Involvement In Disease Dysregulation of KGF is associated with psoriasis, gingival hyperplasia, idiopathic pulmonary fibrosis (IPF), inflammatory bowel disease (IBD), mucositis, interstitial cystitis, and tumorigenesis in stomach, colon, pancreas, and ovarian cancers.

FAQs

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Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.

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