Recombinant Human InsR (R1201Q) Protein

Beta LifeScience SKU/CAT #: BL-0109SG
Recombinant Human InsR (R1201Q) Protein

Recombinant Human InsR (R1201Q) Protein

Beta LifeScience SKU/CAT #: BL-0109SG
Catalog No.: BL-0109SG

Product Overview

Tag GST
Host Species Human
Accession NM_000208
Synonym HHF5, CD220
Background InsR is the insulin receptor tyrosine kinase that is involved in insulin signaling. InsR is post-translationally cleaved into two chains, alpha and beta that are covalently linked. Binding of insulin to the InsR stimulates glucose uptake (1). Insulin receptor signaling helps to maintain fuel homeostasis and prevent diabetes. Studies have shown that a conditional knockout of insulin receptor substrate 2 (IRS2) in mouse pancreas beta cells and parts of the brain--including the hypothalamus--increased appetite, lean and fat body mass, linear growth, and insulin resistance that progressed to diabetes. InsR signaling also increases the regeneration of adult beta cells and the central control of nutrient homeostasis (2).
Description Recombinant human InsR (R1201Q) (980-1382) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.
Source Sf9 insect cells
AA Sequence 980-1382
Molecular Weight 72 kDa
Purity For specific purity information on a given lot, see related COA.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Active
Formulation Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
Stability The recombinant protein is stable for up to 12 months at -70°C
Usage For Research Use Only
Storage Recombinant Human InsR (R1201Q) Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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