Recombinant Human IFN-omega Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2562
Recombinant Human IFN-omega Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2562
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | His |
Host Species | Human |
Accession | P05000 |
Synonym | IFN-omega 1, IFNW1, interferon omega-1 |
Background | IFNs are a large family of proteins having antiviral, antiproliferative, and immunomodulatory effects, and are divided into two major classes, type I and type II, on the basis of differences in receptor binding and nucleotide sequence. Type I IFNs consist of IFN alpha, beta, τ, and ω and bind to the type I IFN receptor, whereas IFN-γ is the only type II IFN and is specific for the type II IFN receptor. Human IFN-ω, was identified by three independent groups in 1985 and is structurally related to IFN-alpha and -beta. Both human IFN-ω and IFN-alpha are produced by virally induced leukocytes and have similar antiviral activities on human cell lines, and a sizeable proportion (at least 1%) of the total antiviral activity of leukocyte IFN is contributed by IFN-ωl. In addition, it was reported that IFN-ω could inhibit the growth of human tumors in vivo. |
Description | A DNA sequence encoding the human IFNW1 (P05000) (Met1-Ser195) was expressed with a His tag at the C-terminus. |
Source | HEK293 |
Predicted N Terminal | Leu 22 |
AA Sequence | Met1-Ser195 |
Molecular Weight | The recombinant human IFNW1 consists of 185 a.a. and predicts a molecular mass of 21.6 KDa. It migrates as an approximately 22 KDa band in SDS-PAGE under reducing conditions. |
Purity | >95% as determined by SDS-PAGE |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Bioactivity | Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus(VSV).The ED50 for this effect is typically 2-8 pg/mL. |
Formulation | Lyophilized from sterile PBS, pH 7.4. |
Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
Usage | For Research Use Only |
Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Target Details
Subcellular Location | Secreted. |
Protein Families | Alpha/beta interferon family |
Database References |
Gene Functions References
- a review on current status in clinical applications of interferon-omega PMID: 28957693
- Single nucleotide polymorphism in ACO1 gene is associated with skin pigmentation. PMID: 20574843
- Data show that a novel c.1344delC mutation in AIRE and anti-IFN-omega antibodies appear very early in life are helpful to differentiate APS I from other multi-organ autoimmune diseases. PMID: 19863576