Human HTRA1 (Serine Protease Htra1) - Recombinant Protein
Beta LifeScience
SKU/CAT #: BLT-07624P
SDS-PAGE analysis of Human HTRA1 (Serine Protease Htra1) - Recombinant Protein, CAT# BLT-07624P, showing >90% purity under 15% SDS-PAGE (Reduced)
Human HTRA1 (Serine Protease Htra1) - Recombinant Protein
Beta LifeScience
SKU/CAT #: BLT-07624P
Regular price
$69500
$695.00
Sale price$55600
$556.00Save $139
/
Quantity Pricing
| Pack Size | Price (USD) |
|---|---|
| 500 µg | $1,206.00 Original price: |
| 1 mg | $2,284.00 Original price: |
For direct online orders, quantity pricing will be displayed in cart when you add 5x100ug or 10x100ug
Submit an inquiry or email inquiry@betalifesci.com for a customization request or bulk order quote.
Connect with us via the live chat in the bottom corner to receive immediate assistance.
Product Overview
| Product Name | Recombinant Human High Temperature Requirement Factor A1 (HTRA1) Protein |
| Product Overview | This recombinant human High Temperature Requirement Factor A1 (HTRA1) protein includes amino acids 204-364aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in PBSprior to lyophilization. |
| Target Uniprot Id | Q92743 |
| Recommended Name | Serine protease HTRA1 |
| Gene Name | HTRA1 |
| Synonyms | HtrA; L56; ORF480; PRSS11 |
| Species | Human |
| Predicted Molecular Mass | 47 kDa |
| Expression System | E.coli |
| Expression Range | 204-364aa |
| Tag | N-His-GST |
| Purity | >90% |
| Formulation | Lyophilized |
| Buffer | PBS |
| Storage Condition | 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction | Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications | Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area | Signal Transduction |
| Target Function | Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets. |
| Subcellular Location | Cell membrane. Secreted. Cytoplasm, cytosol. |
| Protein Family | Peptidase S1C family |
| Associated Diseases | Macular degeneration, age-related, 7 (ARMD7); Cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy (CARASIL); Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, 2 (CADASIL2) |
| Tissue Specificity | Widely expressed, with strongest expression in placenta (at protein level). Secreted by synovial fibroblasts. Up-regulated in osteoarthritis and rheumatoid arthritis synovial fluids and cartilage as compared with non-arthritic (at protein level). |
