Recombinant Human HDAC4 Protein

Beta LifeScience SKU/CAT #: BL-0249SG
Recombinant Human HDAC4 Protein

Recombinant Human HDAC4 Protein

Beta LifeScience SKU/CAT #: BL-0249SG
Catalog No.: BL-0249SG

Product Overview

Tag GST
Host Species Human
Accession NM_006037
Synonym HA6116; HD4; HDAC-A; HDACA; KIAA0288
Background HDAC4 or Histone deacetylase 4 belongs to class II of the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex that represses transcription when tethered to a promoter. HDAC4 does not bind DNA directly, but through transcription factors MEF2C and MEF2D. Binding of the N terminus of HDAC4 to MEF2C represses MEF2C transcription activity. The catalytic domain of HDAC4 interacts with HDAC3 via the transcriptional corepressor NCOR2. Suppression of HDAC4 binding to NCOR2 and to HDAC3 results in loss of enzymatic activity associated with HDAC4.
Description Recombinant human HDAC4 (101-end) was produced by baculovirus in Sf9 insect cells using an C-terminal GST tag. This protein is purified with our unique purification methods.
Source Sf9 insect cells
AA Sequence 101a.a.-end
Molecular Weight 155 kDa
Purity For specific purity information on a given lot, see related COA.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Active
Formulation Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
Stability The recombinant protein is stable for up to 12 months at -70°C
Usage For Research Use Only
Storage Recombinant Human HDAC4 Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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