Recombinant Human HDAC4 Protein
Beta LifeScience
SKU/CAT #: BL-0249SG
Recombinant Human HDAC4 Protein
Beta LifeScience
SKU/CAT #: BL-0249SG
Catalog No.: BL-0249SG
Product Overview
| Tag | GST |
| Host Species | Human |
| Accession | NM_006037 |
| Synonym | HA6116; HD4; HDAC-A; HDACA; KIAA0288 |
| Background | HDAC4 or Histone deacetylase 4 belongs to class II of the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex that represses transcription when tethered to a promoter. HDAC4 does not bind DNA directly, but through transcription factors MEF2C and MEF2D. Binding of the N terminus of HDAC4 to MEF2C represses MEF2C transcription activity. The catalytic domain of HDAC4 interacts with HDAC3 via the transcriptional corepressor NCOR2. Suppression of HDAC4 binding to NCOR2 and to HDAC3 results in loss of enzymatic activity associated with HDAC4. |
| Description | Recombinant human HDAC4 (101-end) was produced by baculovirus in Sf9 insect cells using an C-terminal GST tag. This protein is purified with our unique purification methods. |
| Source | Sf9 insect cells |
| AA Sequence | 101a.a.-end |
| Molecular Weight | 155 kDa |
| Purity | For specific purity information on a given lot, see related COA. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Active |
| Formulation | Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol. |
| Stability | The recombinant protein is stable for up to 12 months at -70°C |
| Usage | For Research Use Only |
| Storage | Recombinant Human HDAC4 Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
