Recombinant Human Glutamate Receptor 3 (GRIA3) Protein (His)
Beta LifeScience
SKU/CAT #: BLC-09530P
Greater than 90% as determined by SDS-PAGE.
Recombinant Human Glutamate Receptor 3 (GRIA3) Protein (His)
Beta LifeScience
SKU/CAT #: BLC-09530P
Collections: High-quality recombinant proteins, Other recombinant proteins
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
| Description | Recombinant Human Glutamate Receptor 3 (GRIA3) Protein (His) is produced by our Yeast expression system. This is a protein fragment. |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Uniprotkb | P42263 |
| Target Symbol | GRIA3 |
| Synonyms | AMPA 3; AMPA selective glutamate receptor 3; AMPA-selective glutamate receptor 3; dJ1171F9.1; GluA3; GLUK3; GluR 3; GLUR C; GLUR K3; GluR-3; GluR-C; GluR-K3; GLUR3; GLURC; Glutamate ionotropic receptor AMPA type subunit 3; Glutamate receptor 3; Glutamate receptor C; Glutamate receptor ionotrophic AMPA 3; Glutamate receptor ionotropic; Glutamate receptor subunit 3; Glutamate receptor; ionotropic; AMPA 3; GRIA 3; Gria3; GRIA3_HUMAN; Ionotrophic Glutamate Receptor; MRX94 |
| Species | Homo sapiens (Human) |
| Expression System | Yeast |
| Tag | N-6His |
| Target Protein Sequence | SLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANL |
| Expression Range | 151-250aa |
| Protein Length | Partial |
| Mol. Weight | 14.0kDa |
| Research Area | Neuroscience |
| Form | Liquid or Lyophilized powder |
| Buffer | Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
| Reconstitution | Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Storage | 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Target Details
| Target Function | Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. |
| Protein Families | Glutamate-gated ion channel (TC 1.A.10.1) family, GRIA3 subfamily |
| Database References | HGNC: 4573 OMIM: 300699 KEGG: hsa:2892 STRING: 9606.ENSP00000264357 UniGene: PMID: 29016847 |
