Recombinant Human FRZB Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2154
Recombinant Human FRZB Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2154
Catalog No.: BLPSN-2154
Product Overview
| Tag | His |
| Host Species | Human |
| Accession | NP_001454.2 |
| Synonym | FRE, FRITZ, FRP-3, FRZB-1, FRZB-PEN, FRZB1, FZRB, hFIZ, OS1, SFRP3, SRFP3 |
| Background | FRZB also known as sFRP-3, is a secreted protein containing a domain similar to the putative Wnt-binding region of the frizzled family of transmembrane receptors. FRZB is widely expressed in adult mammalian tissues. In the Xenopus gastrula, FRZB is regulated as a typical Spemann organizer component. FRZB also functions as a competitor for the cell-surface G-protein receptor Frizzled. It is espically important in embryonic development. Defects in FRZB gene can cause female-specific osteoarthritis (OA) susceptibility. FRZB may serve an important role in determining hip shape and may modify the relationship between hip shape and OA. |
| Description | A DNA sequence encoding the human FRZB (NP_001454.2) (Ala32-Asn325) was expressed with a C-terminal His tag. |
| Source | HEK293 |
| Predicted N Terminal | Ala 32 |
| AA Sequence | Ala32-Asn325 |
| Molecular Weight | The recombinant human FRZB comprises 304 a.a. and has a predicted molecular mass of 34.5 kDa. The apparent molecular mass of the protein is approximately 41 kDa in SDS-PAGE under reducing conditions. |
| Purity | >85% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
