Recombinant Human FRZB Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-2154
Recombinant Human FRZB Protein (His Tag)

Recombinant Human FRZB Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-2154
Catalog No.: BLPSN-2154

Product Overview

Tag His
Host Species Human
Accession NP_001454.2
Synonym FRE, FRITZ, FRP-3, FRZB-1, FRZB-PEN, FRZB1, FZRB, hFIZ, OS1, SFRP3, SRFP3
Background FRZB also known as sFRP-3, is a secreted protein containing a domain similar to the putative Wnt-binding region of the frizzled family of transmembrane receptors. FRZB is widely expressed in adult mammalian tissues. In the Xenopus gastrula, FRZB is regulated as a typical Spemann organizer component. FRZB also functions as a competitor for the cell-surface G-protein receptor Frizzled. It is espically important in embryonic development. Defects in FRZB gene can cause female-specific osteoarthritis (OA) susceptibility. FRZB may serve an important role in determining hip shape and may modify the relationship between hip shape and OA.
Description A DNA sequence encoding the human FRZB (NP_001454.2) (Ala32-Asn325) was expressed with a C-terminal His tag.
Source HEK293
Predicted N Terminal Ala 32
AA Sequence Ala32-Asn325
Molecular Weight The recombinant human FRZB comprises 304 a.a. and has a predicted molecular mass of 34.5 kDa. The apparent molecular mass of the protein is approximately 41 kDa in SDS-PAGE under reducing conditions.
Purity >85% as determined by SDS-PAGE
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.4..
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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