Recombinant Human FGFR1 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2055
Recombinant Human FGFR1 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2055
Catalog No.: BLPSN-2055
Product Overview
| Tag | His |
| Host Species | Human |
| Accession | NP_075594.1 |
| Synonym | FGFR1, BFGFR, CD331, CEK, FGFBR, FGFR-1, FLG, FLT-2, FLT2, HBGFR, HH2, HRTFDS, KAL2, N-SAM, OGD, bFGF-R-1, ECCL, fibroblast growth factor receptor 1 |
| Background | Fibroblast growth factor receptor 1 (FGFR1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. FGFR1 has been shown to be associated with Pfeiffer syndrome.FGFR1 is a member of the fibroblast growth factor receptor (FGFR) family, which in addition to FGFR1, includes FGFR2, FGFR3, FGFR4, and FGFRL1. FGFR1-4 are cell surface membrane receptors that possess tyrosine kinase activity. |
| Description | A DNA sequence encoding the human FGFR1 (NP_075594.1) extracellular domain (Met 1-Glu 285) was expressed with C-terminal His tag. |
| Source | HEK293 |
| Predicted N Terminal | Arg 22 |
| AA Sequence | Met 1-Glu 285 |
| Molecular Weight | The secreted recombinant human FGFR1 consists of 275 amino acids and has a predicted molecular mass of 31 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh FGFR1 monomer is approximately 50-55 kDa due to glycosylation. |
| Purity | >98% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Measured by its ability to inhibit FGF acidic dependent proliferation of Balb/C 3T3 mouse fibroblasts.The ED50 for this effect is typically 0.1-0.6 ug/mL. |
| Formulation | Recombinant Human FGFR1 Protein (His Tag) was lyophilized from sterile PBS, pH 7.4 |
| Stability | Recombinant Human FGFR1 protein is stable up to 1 year at -70°C |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
