Recombinant Human FGF21 Protein
Beta LifeScience
SKU/CAT #: BL-1646SG
Recombinant Human FGF21 Protein
Beta LifeScience
SKU/CAT #: BL-1646SG
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | N/A |
Host Species | Human |
Accession | Q9NSA1 |
Synonym | FGF-21, Recombinant Human Fibroblast Growth Factor 21 (FGF21). |
Background | FGF21 is a secreted growth factor of the FGF family, classified as an FGF19 subfamily member. Proteins of the FGF family are known to play a central role with respect to both prenatal and postnatal growth and development, and regeneration of a variety of tissues by promoting cellular proliferation and differentiation. In the presence of beta Klotho (protein cofactor), FGF21 signals via the FGFR receptors to stimulate insulin independent glucose uptake by adipocytes. |
Description | Recombinant Human FGF21 was produced in E. coli. This protein is purified with our unique purification methods. |
Source | E.coli |
Molecular Weight | 19.7 kDa |
Purity | For specific purity information on a given lot, see related COA. |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Formulation | Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol. |
Stability | The recombinant protein is stable for up to 12 months at -70°C |
Usage | For Research Use Only |
Storage | Recombinant Human FGF21 Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Target Details
Target Function | Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Regulates systemic glucose homeostasis and insulin sensitivity. |
Subcellular Location | Secreted. |
Protein Families | Heparin-binding growth factors family |
Database References | HGNC: 3678 OMIM: 609436 KEGG: hsa:26291 STRING: 9606.ENSP00000222157 UniGene: PMID: 29953859 |