Recombinant Human DR6 Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BL-0077NP
Recombinant Human DR6 Protein (Fc Tag)

Recombinant Human DR6 Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BL-0077NP
Catalog No.: BL-0077NP

Product Overview

Tag Fc
Host Species Human
Accession O75509
Synonym DR6 Tumor Necrosis Factor Receptor Superfamily Member 21; Death Receptor 6; CD358; TNFRSF21; DR6; UNQ437/PRO868
Background Tumor Necrosis Factor Receptor Superfamily Member 21 (TNFRSF21) is a type I transmembrane receptor that includes four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. DR6 may activate NF-kappa-B and JNK to promote apoptosis and T-cell differentiation. In addition, DR6 binds with N-APP, which is released by the deprivation of Trophic-factor. It triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). DR6 is also expressed on the tumor cell lines and can be induced by TNF-alpha.
Description Recombinant Human Death Receptor 6 is expressed by our Mammalian expression system and the target gene encoding Gln42-Leu350 is expressed with a Fc tag at the C-terminus.
Source Human Cells
AA Sequence Gln42-Leu350
Purity >95% as determined by reducing SDS-PAGE.
Endotoxin <0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Recombinant Human DR6 Protein was lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Dissolve the lyophilized protein in distilled water.
Usage For Research Use Only
Storage Human DR6 protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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