Recombinant Human DEFB4A Protein
Beta LifeScience
SKU/CAT #: BL-2624NP

BL-2624NP: Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Recombinant Human DEFB4A Protein
Beta LifeScience
SKU/CAT #: BL-2624NP
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Description | Recombinant Human Beta-Defensin 4A is produced by our E.coli expression system and the target gene encoding Gly24-Pro64 is expressed. |
Accession | O15263 |
Synonym | Beta-Defensin 4A; Beta-Defensin 2; BD-2; hBD-2; Defensin; Beta 2; Skin-Antimicrobial Peptide 1; SAP1; DEFB4A; DEFB102; DEFB2; DEFB4; DEFB4B |
Gene Background | β-Defensin 4A is a membrane-active cationic peptide that functions in inflammation and innate immune responses. There are at least 30 β-Defensins, which are distinguished from α-Defensins by the connectivity pattern of their three intermolecular disulfide bonds. Members of the Defensin family are highly similar in protein sequence. This gene encodes Defensin, DEFB4;, which has broad-spectrum antimicrobial activity and may play an important role in innate epithelial defense. They are highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. β-Defensin 4A has low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine. The 45 amino acid mature human BD3 shares 38% and 33% amino acid sequence identity with mouse and rat BD3, respectively. |
Molecular Mass | 4.33 KDa |
Apmol Mass | 9 KDa, reducing conditions |
Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
Biological Activity | Not tested |
Reconstitution | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Storage | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
Usage | For Research Use Only |
Target Details
Target Function | Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells. |
Subcellular Location | Secreted. |
Protein Families | Beta-defensin family, LAP/TAP subfamily |
Database References | |
Tissue Specificity | Expressed in the skin and respiratory tract. |
Gene Functions References
- The encoded peptide has antimicrobial activity against E.coli, S. aureus, and P. aeruginosa. PMID: 9727055