Name: Recombinant Human BTK (C481F) Protein
Brand: Beta LifeScience
SKU: BL-0131SG
Availability: InStock

Catalog No.: BL-0131SG

Product Overview

Tag	His
Host Species	Human
Accession	NM_000061
Synonym	AT; ATK; BPK; XLA; IMD1; AGMX1; PSCTK
Background	BTK (also known as Bruton tyrosine kinase) plays a crucial role in B-lymphocyte differentiation and activation. BTK interacts with SRC homology 3 domains of FYN, LYN and HCK that are activated upon stimulation of B- and T-cell receptors (1).Defects in the BTK gene cause Agammaglobulinemia, an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. The unique role of BTK makes it a desirable target for potential anti-cancer, anti-inflammatory and anti-viral agents as well as other treatments (2).
Description	Recombinant full-length human BTK (C481F) was produced by baculovirus in Sf9 insect cells, fused with a His tag at N-terminus.
Source	Sf9 insect cells
AA Sequence	Full Length
Molecular Weight	~75 kDa
Purity	For specific purity information on a given lot, see related COA.
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity	Active
Formulation	Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
Stability	The recombinant protein is stable for up to 12 months at -70°C
Usage	For Research Use Only
Storage	Recombinant Human BTK (C481F) Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.