Recombinant Human BMP-4 Protein, Active

Beta LifeScience SKU/CAT #: BEP-0053

Recombinant Human BMP-4 Protein, Active

Beta LifeScience SKU/CAT #: BEP-0053
/
Size

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Product Overview

Product Name Recombinant Human BMP-4 Protein
Target Symbol BMP4
Alternative Names Bone Morphogenetic Protein 4, Bone Morphogenetic Protein 2B, BMP4, BMP2B, BMP2B1, MCOPS6, OFC11, ZYME, DVR4, ZBMP4
Accession Number P12644.1
Expression System Mammalian cell line.
Molecular Weight 13 kDa (monomer, predicted)
Sequence Ser293-Arg408
Purity Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining
Activity Determined by in-house activity assay
Formulation Lyophilized from sterile PBS with Trehalose, pH 7.4
Endotoxin Level Available Upon Request
Shipping Shipped at ambient temperature.
Stability & Storage 12 months from date of receipt at -20°C to -70°C, lyophilized powder. 3 months at -20°C to -70°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw cycles.
Reconstitution Reconstitute at 100 ug/mL in sterile PBS.
Target Function Bone Morphogenetic Protein 4 (BMP-4) plays roles across bone formation, embryonic development, organogenesis, cell differentiation and tissue repair. BMP-4 promotes the differentiation of mesenchymal stem cells into osteoblasts, as well as differentiation of neuronal precursors, cardiac progenitors, kidney progenitors, keratinocyte differentiation, odontoblast differentiation, adipocyte differentiation, and regulation of ovarian follicle development. Within the ectoderm and mesoderm, BMP-4 contributes to dorsal-ventral patterning of the developing neural tube, as well as additional patterning leading to development of lung, bone, kidney, eye, heart, muscle and limbs. In response to tissue damage, BMP-4 promotes migration of keratinocytes and angiogenesis. BMP-4 signaling occurs via binding to BMPR1A (CD292) and BMPR2, at which point BMPR2 transphosphorylates BMPR1A to induce the Smad signaling pathway.
Tissue Specificity BMP-4 expression has been identified in ectoderm, mesoderm, endoderm, developing skeletal tissues such as cartilage and bone, the developing central nervous system, including the neural tube and the brain, heart, kidney, lung, skin, ovaries, testes, and tooth bud.
Cellular Localization Secreted protein
Involvement In Disease Dysregulation of BMP-4 is associated with osteoporosis, skeletal dysplasias, craniofacial abnormalities such as cleft lip and palate, pulmonary arterial hypertension, atherosclerosis, cardiac fibrosis, Alzheimer’s disease, Parkinson’s disease, insulin resistance, obesity, metabolic syndrome, polycystic kidney disease, renal fibrosis, diabetic nephropathy, rheumatoid arthritis, osteoarthritis, and various cancers due to BMP-4 enhanced cell proliferation, apoptosis, invasion, and metastasis of cancer cells.

FAQs

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Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.

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