Recombinant Human BIRC7 Protein

Beta LifeScience SKU/CAT #: BL-0157SG
Recombinant Human BIRC7 Protein

Recombinant Human BIRC7 Protein

Beta LifeScience SKU/CAT #: BL-0157SG
Catalog No.: BL-0157SG

Product Overview

Tag GST
Host Species Human
Accession BC014475
Synonym KIAP; LIVIN; ML-IAP; MLIAP; RNF50
Background Baculoviral IAP repeat-containing protein 7 (BIRC7) is a member of the newly discovered inhibitor of apoptosis proteins (IAPs) family whose activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase. Highly expressed in tumor tissues and inhibits tumor cell apoptosis through blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. BIRC7 expression in breast cancer correlated with the clinical stage and axillary lymph node metastasis, and promotes breast cancer metastasis through the activation of AKT signaling and induction of EMT in breast cancer cells.
Description Recombinant full-length human BIRC7 was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods. This protein is purified with our unique purification methods.
Source Sf9 insect cells
AA Sequence Full Length
Molecular Weight 60 kDa
Purity For specific purity information on a given lot, see related COA.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Active
Formulation Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
Stability The recombinant protein is stable for up to 12 months at -70°C
Usage For Research Use Only
Storage Recombinant Human BIRC7 Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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