Recombinant Human ATR Protein
Beta LifeScience
SKU/CAT #: BL-1108SG
Recombinant Human ATR Protein
Beta LifeScience
SKU/CAT #: BL-1108SG
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | GST |
Host Species | Human |
Accession | NM_001184 |
Synonym | FRP1, MEC1, SCKL, SCKL1 |
Background | ATR belongs to the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase which share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. ATR is shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. ATR is an essential regulator of genomic integrity, controls and coordinates DNA-replication origin firing, replication-fork stability, cell cycle checkpoints, and DNA repair (1). ATR/ATM-dependent phosphorylation of RAD17 is a critical early event during checkpoint signaling in DNA-damaged cells (2). |
Description | Recombinant human ATR (2245-end) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods. |
Source | Sf9 insect cells |
AA Sequence | 2245a.a.-end |
Molecular Weight | 70 kDa |
Purity | For specific purity information on a given lot, see related COA. |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Formulation | Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol. |
Stability | The recombinant protein is stable for up to 12 months at -70°C |
Usage | For Research Use Only |
Storage | Recombinant Human ATR Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |