Recombinant Human ALK (F1174S) Protein

Beta LifeScience SKU/CAT #: BL-0256SG
Recombinant Human ALK (F1174S) Protein

Recombinant Human ALK (F1174S) Protein

Beta LifeScience SKU/CAT #: BL-0256SG
Catalog No.: BL-0256SG

Product Overview

Tag GST
Host Species Human
Accession NM_004304
Synonym ALK (Ki-1), CD246, NBLST3, TFG/ALK
Background ALK or anaplastic lymphoma kinase is a receptor tyrosine kinase that was originally identified as a member of the insulin receptor subfamily that acquires transforming capability when truncated and fused to NPM (nucleophosmin) in the t(2;5) chromosomal rearrangement associated with ALCL Many chromosomal rearrangements leading to enhanced ALK activity have been described and are implicated in a number of cancer types (1). In the nervous system, ALK in the presence of ligand appears essential for axonal guidance, whereas in the absence of ligand, ALK expression can lead to developmental neuronal apoptosis (2).
Description Recombinant human ALK (F1174S) (1060-end) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.
Source Sf9 insect cells
AA Sequence 1060a.a.-end
Purity For specific purity information on a given lot, see related COA.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Active
Formulation Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
Stability The recombinant protein is stable for up to 12 months at -70°C
Usage For Research Use Only
Storage Recombinant Human ALK (F1174S) Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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