Recombinant Cynomolgus IFNA4 Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2523
Recombinant Cynomolgus IFNA4 Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2523
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | Fc |
Host Species | Cynomolgus |
Synonym | IFNA4 |
Background | Interferon, alpha 4 (IFNA4) belongs to the alpha/beta interferon family. Two variants of IFNA4 (IFNA4a and IFNA4b) are known, which differ from each other by changes in their coding regions at nucleotide positions 22 and 41 and can be distinguished by selective restriction enzyme analysis. Interferons are produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. IFN-alpha, the first cytokine to be produced by recombinant DNA technology, has emerged as an important regulator of growth and differentiation, affecting cellular communication and signal transduction pathways as well as immunological control. Originally discovered as an antiviral substance, the efficacy of IFN-alpha in malignant, viral, immunological, angiogenic, inflammatory, and fibrotic diseases suggests a spectrum of interrelated pathophysiologies. IFN-alpha emerged as a prototypic tumor suppressor protein that represses the clinical tumorigenic phenotype in some malignancies capable of differentiation. |
Description | A DNA sequence encoding the cynomolgus IFNA4 (Met1-Asn189) was expressed with Fc region of mouse IgG at the C-terminus. |
Source | HEK293 |
Predicted N Terminal | Cys 24 |
AA Sequence | Met1-Asn189 |
Molecular Weight | The recombinant cynomolgus IFNA4 is a disulfide-linked homodimer. The reduced monomer comprises 400 a.a. and has a calculated molecular mass of 45.6 KDa.The apparent molecular mass of the protein is approximately 48 KDa respectively in SDS-PAGE. |
Purity | >90% as determined by SDS-PAGE |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Bioactivity | Measured in antiviral assay using WISH human amnion cells infected with vesicular stomatitisvirus (VSV).The ED50 for this effect is 0.03-0.3 ng/mL. |
Formulation | Lyophilized from sterile PBS, pH 7.4. |
Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
Usage | For Research Use Only |
Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |