Recombinant Cynomolgus Fractalkine / CX3CL1 Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2134
Recombinant Cynomolgus Fractalkine / CX3CL1 Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2134
Catalog No.: BLPSN-2134
Product Overview
| Tag | Fc |
| Host Species | Cynomolgus |
| Background | Fractalkine or Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a member of the CX3C chemokine family. Fractalkine / CX3CL1 is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferon-gamma and tumor necrosis factor-alpha. Fractalkine/CX3CL1 is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, monocytes and NK cells. Fractalkine / CX3CL1 is associated with dendritic cells (DC) in epidermis and lymphoid organs. The fractalkine receptor, CX3CR1, is expressed on cytotoxic effector lymphocytes, including natural killer (NK) cells and cytotoxic T lymphocytes, which contain high levels of intracellular perforin and granzyme B, and on macrophages. Soluble fractalkine causes migration of NK cells, cytotoxic T lymphocytes, and macrophages, whereas the membrane-bound form captures and enhances the subsequent migration of these cells in response to secondary stimulation with other chemokines. |
| Description | A DNA sequence encoding the cynomolgus CX3CL1 (EHH60415.1) (Met1-Gly100) was expressed with the Fc region of human IgG1 at the C-terminus. Cynomolgus and Rhesus CX3CL1 sequences are identical. |
| Source | HEK293 |
| Predicted N Terminal | Gln 25 |
| AA Sequence | Met1-Gly100 |
| Molecular Weight | The recombinant cynomolgus CX3CL1 comprises 317 a.a. and has a calculated molecular mass of 35.7 KDa. The apparent molecular mass of it is approximately 40.8 and 35.2 KDa respectively in SDS-PAGE under reducing conditions. |
| Purity | (90.9+6.8)% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
