Recombinant Cynomolgus Fractalkine / CX3CL1 Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BLPSN-2134
Recombinant Cynomolgus Fractalkine / CX3CL1 Protein (Fc Tag)

Recombinant Cynomolgus Fractalkine / CX3CL1 Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BLPSN-2134
Catalog No.: BLPSN-2134

Product Overview

Tag Fc
Host Species Cynomolgus
Background Fractalkine or Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a member of the CX3C chemokine family. Fractalkine / CX3CL1 is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferon-gamma and tumor necrosis factor-alpha. Fractalkine/CX3CL1 is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, monocytes and NK cells. Fractalkine / CX3CL1 is associated with dendritic cells (DC) in epidermis and lymphoid organs. The fractalkine receptor, CX3CR1, is expressed on cytotoxic effector lymphocytes, including natural killer (NK) cells and cytotoxic T lymphocytes, which contain high levels of intracellular perforin and granzyme B, and on macrophages. Soluble fractalkine causes migration of NK cells, cytotoxic T lymphocytes, and macrophages, whereas the membrane-bound form captures and enhances the subsequent migration of these cells in response to secondary stimulation with other chemokines.
Description A DNA sequence encoding the cynomolgus CX3CL1 (EHH60415.1) (Met1-Gly100) was expressed with the Fc region of human IgG1 at the C-terminus. Cynomolgus and Rhesus CX3CL1 sequences are identical.
Source HEK293
Predicted N Terminal Gln 25
AA Sequence Met1-Gly100
Molecular Weight The recombinant cynomolgus CX3CL1 comprises 317 a.a. and has a calculated molecular mass of 35.7 KDa. The apparent molecular mass of it is approximately 40.8 and 35.2 KDa respectively in SDS-PAGE under reducing conditions.
Purity (90.9+6.8)% as determined by SDS-PAGE
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.4..
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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